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Biotech / Medical : ASTM-AASTROM BIOSCIENCES: STEM CELL RESEARCH -- Ignore unavailable to you. Want to Upgrade?

To: Curbstone who wrote (282)	12/11/1998 11:27:00 AM
From: campe	Read Replies (1) \| Respond to of 1084

Good questions about ASTM technology. ASTM has patented technologies... aastrom.com Patent Summary Aastrom's patent portfolio broadly covers process and composition of matter claims for the ex vivo production of human stem cells and the ex vivo genetic modification of stem cells, as well as the differentiation of key blood and immune system cells derived from human stem cells. If you are interested in receiving a copy of any of the following patents, please contact Aastrom. U.S. Patent 5,646,043 - “Methods for the Ex Vivo Replication of Human Stem Cells and/or Expansion of Human Progenitor Cells” Broadly covers methods for the replication of human stem cells in culture, including perfusion of the medium U.S. Patent 5,635,386 - “Methods for Regulating the Specific Lineages of Cells Produced in a Human Hematopoietic Cell Culture” Covers processes essential for the differentiation of key blood and immune cells in ex vivo cultures, and extends the scope of claims for processes for growing human hematopoietic stem cells and methods to enhance the production of certain tissue-specific cell types that originate from stem cells. U.S. Patent 5,688,687 - “Bioreactor for Mammalian Cell Growth and Maintenance” Covers Aastrom's cell culture chamber for the ex vivo production of human cells, including stem cells. U.S. Patent 5,670,351 - “Methods and Compositions for the Ex Vivo Replication of Human Hematopoietic Stem Cells” Covers composition of matter and therapeutic uses of ex vivo produced human stem cells as well as methods for obtaining gene-modified cells. U.S. Patent 5,670,147 - “Compositions Containing Cultured Mitotic Human Stem Cells” Covers composition of matter and therapeutic uses of ex vivo produced human stem cells as well as methods for obtaining gene-modified cells. U.S. Patent 4,839,292 - "Cell Culture Device Utilizing a Membrane for Internal Oxygenation" Covers cell culture devices utilizing a permeable membrane to separate an internal gas chamber from the cell growth chamber which allows for efficient and uniform oxygenation of cells. U.S. Patent 5,459,069 - "Cell Culture Device With Variable Perfusion and Radial Fluid Flow" The first U.S. Patent to describe device technology which enables the growth and production of human stem cells nd other tissues outside the body. The device provides for simultaneous, single-pass, variable medium profusion and internal oxygenation of multiple cell types including both adherent and non-adherent cells. U.S. Patent 5,605,822 - "Methods, Compositions and Devices for Growing Human Hematopoietic Cells" Covers methods, compositions and devices for growing multiple cells in the presence of continuously maintained levels of nutrients and growth factors while removing undesirable metabolic products. U.S. Patent 5,437,994 "Replication of Human Stem Cells and Replication and Production of Human and Progenitor Cells" Covers methods for the ex vivo replication of stem cells and for the optimization of hematopoietic progenitor cell cultures. U.S. Patent 5,763,266 "Methods, Compositions and Devices for Maintaining and Growing Human Stem and/or Hematopoietic Cells" Methods, compositions and devices are provided for the growth of human stem and/or hematopoietic cells in culture. Bioreactors are provided in which diverse cell types are simultaneously cultured in the presence of appropriate levels of nutrients and growth factors substantially continuously maintained in the bioreactor while removing undesirable metabolic products. This simultaneous culture of multiple cell types successfully reconstructs hematopoietic tissue ex vivo. U.S. Patent 5,399,493 "Production of Genetically Modified Human Stem Cells and Progenitor Cells" Covers ex vivo processes for stable gene transduction into human stem cells. U.S. Patent 5,534,423 "Increasing Rates of Infection by Directing Motion of Vectors" Covers methods of increasing the frequency of contact between vectors and stationary target cells to overcome limitations imposed by random Brownian motion. The methods include flow-through of liquid containing the vectors past a bed of cells. U.S. Patent 5,616,487 "Stabilized Retrovirus Compositions" Covers a stabilized virus which is modified using a stabilizing agent, and also provides a process for producing a stabilized virus by culturing viral producing cells with a stabilizing agent. The patent also covers methods to introduce an exogenous nucleotide into a cell using a stabilized virus and methods for administering an exogenous nucleotide sequence to a subject using a stabilized virus. U.S. Patent 5,672,494 "Methods of Increasing Rates of Infection by Directing Motion of Vectors" U.S. Patent 5,804,431 "Methods, Compositions and Apparatus for Cell Transfection" U.S. Patent 5,811,274 "Methods, Compositions and Apparatus for Cell Transfection" These three patents cover methods of and devices for increasing the frequency of contact between vector and stationary target cells in an apparatus containing them which involves causing the vectors to move towards the target cells with motion above and beyond random Brownian motion.