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Biotech / Medical : OSI Pharmaceuticals (OSIP) - formerly Oncogene -- Ignore unavailable to you. Want to Upgrade?

To: R. E. Simpson who wrote (20)	12/18/1998 10:08:00 PM
From: scaram(o)uche	Read Replies (1) \| Respond to of 447

Q4 FY earnings are out. No surprises, IMO. biz.yahoo.com No guidance, nothing to indicate that they're not wandering around bumping off of mistakes and praying for successes. Too many projects. Lots of funding now rolling through the labs, but not enough for the net thrown. We need Goddard to eliminate some programs and to perhaps even return some rights to partners. Some guidance regarding additional patent licenses and when they might be expected would be nice too. Finally, we either need an update on the following project or word that it has been dropped. Damn expensive....... J Nat Prod 1998 Jun 26;61(6):791-5 Epolones: novel sesquiterpene-tropolones from fungus OS-F69284 that induce erythropoietin in human cells. Cai P, Smith D, Cunningham B, Brown-Shimer S, Katz B, Pearce C, Venables D, Houck D MYCOsearch, a subsidiary of OSI Pharmaceuticals, 4727 University Drive, Suite 400, Durham, North Carolina 27707, USA. In the course of our screening for small molecule modulators of erythropoietin gene expression, two novel sesquiterpene tropolones and pycnidone were isolated from a culture of OS-F69284 (ATCC 74390). Their structures were elucidated by extensive 1H and 13C NMR spectroscopic studies and chemical reactions. These compounds induced erythropoietin gene expression 5-fold at a concentration of 1-1.6 microM. J Nat Prod 1998 Feb;61(2):290-3 Destruxin-A4 chlorohydrin, a novel destruxin from fungus OS-F68576: isolation, structure determination, and biological activity as an inducer of erythropoietin. Cai P, Smith D, Katz B, Pearce C, Venables D, Houck D MYCOsearch, OSI Pharmaceuticals, Durham, North Carolina 27707, USA. In the course of screening for small-molecule modulators of erythropoietin gene expression, five destruxins were isolated from the fungal culture of OS-F68576. The structures were elucidated by extensive 1H and 13C NMR spectroscopy and by hydrolytic modification. One compound (destruxin-A4 chlorohydrin, 1) is a novel destruxin. All these compounds induced erythropoietin gene expression 5-fold at concentration of 0.2-2 microM.