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Biotech / Medical : Pharmacopeia, Inc. (ACCL) (Prev: PCOP) -- Ignore unavailable to you. Want to Upgrade?

To: scaram(o)uche who wrote (122)	12/27/1998 6:01:00 PM
From: kinkblot	Read Replies (1) \| Respond to of 179

Combinatorial Chemistry: Not Just For Pharmaceuticals. pubs.acs.org Article reviews application of cc to catalysts, polymers and advanced materials such as phosphors. Some of this is out of PCOP's bailiwick, especially cases where properties depend more on extended solid-state structure than on molecular structure. For example, the Bell Labs dielectric work which involves vacuum deposition of thin films. The biggest challenge may be coming up with methods to screen for desired physical properties. For catalysts, below is a simple technique for measuring reaction rates using thermographs, compatible with solid-support synthesis: [excerpt]...... In developing new catalysts, measuring reaction rates is often difficult. At the University of North Carolina, James Morken and graduate student Steven Taylor correlated the reaction rates of a library of 3,150 catalyst candidates supported on resin beads with the amount of heat liberated to the solvent during the reactions. Morken explains, "Police departments use infrared devices to pick up heat produced by children lost in the woods. Similarly, we use a thermographic video camera to find which polymer beads - to which chemicals have been attached - are generating heat. The heat indicates a chemical reaction, and the more heat, generally the better that chemical is as a catalyst." The most active catalysts were those most strongly bound to the beads. .................... From: Today's Chemist at Work, November 1998.

To: scaram(o)uche who wrote (122)	12/28/1998 11:51:00 PM
From: tommysdad	Read Replies (1) \| Respond to of 179

oooh, I love this quote: <<"In the past few years it has become clear to me that combining database mining with rational approaches to drug design would further facilitate lead discovery.">> How pretentious is that? Are we to believe Dr. Merz thought of this first? Maybe this is why Agouron bought Alanex. Or Vertex has a combichem group. Or every big pharma in the world has both computational and combinatorial efforts going -- often on the same project.