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Biotech / Medical : XOMA. Bull or Bear? -- Ignore unavailable to you. Want to Upgrade?

To: Arthur Radley who wrote (8142)	12/29/1998 4:35:00 PM
From: aknahow	Respond to of 17367

Another patent. Is it important? Novel? Who knows? United States Patent 5,854,214 Little, II Dec. 29, 1998 Therapeutic uses of bactericidal/permeability increasing protein products Abstract The present invention provides therapeutic methods for treatment of conditions including the neutralization of the anti-coagulant activity of heparin, inhibition of angiogenesis, tumor and endothelial cell proliferation, and treatment of chronic inflammatory diseases by administration of bactericidal/permeability-increasing (BPI) protein products. NOTE FULL PATENT AVAILABLE Excerpt: DETAILED DESCRIPTION The present invention relates to the administration of bactericidal/permeability-increasing protein (BPI) protein products for the treatment of a variety of therapeutic conditions not directly associated with bacterial infection. While BPI protein products as described herein are useful as potent cytotoxins for gram-negative bacteria and for neutralizing the adverse effects of lipopolysaccharide associated with the cell walls of gram-negative bacteria, a variety of therapeutic effects for BPI protein products not directly associated with the gram-negative bacterial infection have been discovered. Specifically, the invention provides methods for treating conditions not directly associated with gram-negative infections including neutralization of the anti-coagulant activity of heparin, inhibition of tumor and endothelial cell proliferation including cell proliferation associated with angiogenesis and treatment of chronic inflammatory disease states such as arthritis.