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Biotech / Medical : Pharmos (PARS) -- Ignore unavailable to you. Want to Upgrade?


To: BRAVEHEART who wrote (392)1/4/1999 9:05:00 AM
From: yosi s  Read Replies (2) | Respond to of 1386
 
Pars had a financing about a year ago with a convertible debenture. that is mostly converted.
Recently they came with a financing plan. that they have a line of redit of up to 10 Million $ for 18 months. to use at their timing they will give a 7% discount and 10% of shares issues will also get warrants rights at a premium to market price.
There is a good chance tha Pharmos will not need to raise any more money.
Here is why.
They expect tp sign a parnter for Phase 3 study with Dexanabinol and get payment from that.As for timing some time in the next month a short list should be form with final agreement 4-6 month from now.
( They also have a third and final cohort of phase 2 that is 2/3 finished enrolment, so expect that data to be available late Q3 early Q4)
The market for HU 211 another name for Dexanabinol is over Big as for sales it will depend on pricing. right now no treatment exist. There are 350000 to 500,000 patients that will benefif for this indication in USA alone mostly car trauma, expect about same in Europe.
so the market is from 750 million to 1.5 Billion is usa alone.
Possible double that if it get Stroke indication.And double again when marketed in Europe.
Expect them to get 10 to 15 % of sales, and that will be net net.
Since sales of Alrex and Lotemax will cover burn rate by year 2000 this will be profit.
They also are in late phase 3 for Letobra, a combination of alrex and Tobramycin an antibiotic ( eye medication) Small market not blockbuster. The Alrex Lotemax and Le Tobra are done with BOL Boaush and Lomb.
Down the pike the drug by its mechanisme of action can work for IBD(inflamatory bowl disease, in a separate animal study done In Macmaster University in Canada by investigator independent from Pharmos it worket ; a published study, another separate animal study by the USA Army it shows protective against nerve gas .
What I like about this drug, is that different labs , researcher not related to each other found out that it works under its purported mechanisme for different indication....
They are suppose to get an advance on future sales from BOL upon getting NDA application in Europe, expected this year.
If any of this will take place it shoild provide enough cash flow to cover burn rate.
Their Sales of Lotemax and Alrex are growing. Currently they are at 5-6% of new prescription written, they hope to get to 15%.of market share, the combine market for Alrex lotemax is with in range of 180 to
300 million depends on estimates .( Pharmos get 29% from BOL with a net net of 20% ) Alrex is a corticosteroid and the only one with fda approved indication for chronic eye allergy, got very broad indication. Lotemax is basically same but at highe concentration its used is after eye surgery to reduce inflamation. as well as other indications...

They burn rate is 5 million . once exceeded all cash goes into profit.



To: BRAVEHEART who wrote (392)1/4/1999 9:22:00 AM
From: yosi s  Respond to of 1386
 
"...for relatives with conditions like Alzheimer's disease, Parkinson's disease, stroke and traumatic brain injuries. "

Clinton Proposes Partial Funding of Long-Term Care for
Elderly

Related Articles
Issue in Depth: Health Care

By ROBERT PEAR

ASHINGTON -- President Clinton will announce a $6 billion package of tax and budget proposals on
Monday to help provide long-term care for people with chronic illnesses or disabilities, administration
officials said Sunday.

The proposals represent the most ambitious effort to deal with the long-term care needs of the elderly since the
collapse of Clinton's plan to guarantee health insurance for all Americans in 1994.

The core of the initiative is a proposal to give a tax credit of $1,000 a year to people who need long-term care,
whether at home or in an institution. The tax credit would also be available, in some cases, to people who care
for relatives with conditions like Alzheimer's disease, Parkinson's disease, stroke and traumatic brain injuries.

The White House said that the tax credit, if approved by Congress, would help 2 million people, at a cost of $5.5
billion, from 2000 to 2004.

White House officials said the president would probably not specify now how he intended to pay for the
initiative, but would probably ask Congress to cover the cost by eliminating several corporate tax breaks. In any
event, they said, Clinton will not dip into the anticipated budget surplus, which he has said should be reserved
for Social Security.

Ari Fleischer, a spokesman for Republicans on the House Ways and Means Committee, said the proposed tax
credit for long-term care was "a good idea that has a potential to be enacted into law." It was, he said, part of
the House Republican manifesto, the so-called Contract With America, in 1994 and 1995.

But Fleischer said that Republicans and Democrats alike had in the past resisted some of Clinton's proposals for
business tax increases. The long-term care changes would have a better chance of approval if they were not
linked to tax increases, Fleischer said.

The health initiative is to be included in the budget that Clinton sends to Congress later this month. It responds
to a significant need, administration officials say, pointing out that 5 million Americans need long-term care
because of illness or disability, and that the need will grow with the aging of the population.

The president's proposals would encourage and reward people who provide informal, unpaid care to spouses and
parents. Many of these caregivers are themselves over the age of 60.

Administration officials cited the plan, which has been in the works since the summer, as evidence that the
president was still able to focus on the needs of the American people, despite his impeachment by the House of
Representatives on Dec. 19.

"If this helps on that front, I'm happy," said an administration official asked about any connection between
Monday's planned announcement and the impeachment proceedings, "but that's not the rationale for it."

Budget documents show that Clinton's initiative also includes these proposals:

-- The federal government would provide $125 million a year to the states -- $625 million over the five years
covered by the initiative -- to assist families caring for relatives with serious illnesses or disabilities. The money
would pay for information, training and counseling, as well as the occasional services of a home health aide or
personal attendant, so that the regular caregiver could get out of the home for a few hours a week. About 250,000
families could be assisted under this program.

-- Medicare officials would disseminate information to all 39 million beneficiaries emphasizing that most
long-term care is not covered by Medicare, the federal health insurance program for the elderly and disabled.
Surveys of the elderly have found that nearly 60 percent of them do not realize Medicare's limitations. The
education campaign would cost $10 million.

-- The federal Office of Personnel Management would make private long-term care insurance available to federal
employees and retirees, their parents and certain in-laws at negotiated group rates. The government would not
pay the premiums, but would negotiate the rates with a single insurer or "a very small number of carriers."

The White House estimates that 300,000 people would buy insurance under this arrangement. Because of the group
rates, it says, premiums would be 15 percent to 20 percent lower than the cost of individual long-term care
policies. The government would insist on certain minimum benefits and a cost-of-living allowance, to protect
benefits against inflation. The administrative costs to the federal government would be $15 million over five
years.

Joshua M. Wiener, an expert on long-term care at the Urban Institute, a research and policy center, welcomed the
president's proposals. "It's good to see some recognition of this issue," he said. "In the debate about Social
Security and Medicare, we've almost totally forgotten the third concern about retirement security -- the need for
long-term care."

But Wiener said the tax credit would be of little help to people with incomes so low that they did not pay
federal income taxes. "You have to pay some taxes to qualify," he said, "and 40 percent of the elderly pay no
income taxes at all, primarily because substantial amounts of Social Security are not counted as income for tax
purposes."

And although a $1,000 credit would be valuable, many people with chronic illnesses and disabilities require
home-care services costing tens of thousands of dollars a year, experts said.

The administration says that three-fourths of the people who would get the proposed credit would be spouses or
other relatives of people needing long-term care.

Under the administration proposal, a person could qualify for the tax credit if he or she was unable to perform
three or more basic tasks of everyday life. These "activities of daily living" include bathing, dressing, eating,
using a toilet and getting in and out of a bed or a chair. The person's impairments would have to be certified by
a doctor.

Alternatively, the family of a person needing long-term care could qualify for the tax credit if the family
provided such care to a close relative who lived with the family and who had annual gross income of less than
$8,100.

The tax credit would be available, in some cases, to parents caring for children with severe disabilities. The rate
of children living with handicaps has increased in recent years, in part because of doctors' success in saving
premature, sick and disabled newborns.

The administration says the tax credit would benefit 1.2 million elderly people, 250,000 children and 550,000
nonelderly adults.

The full tax credit would be available to couples with incomes up to $110,000 a year, but would be gradually
reduced for more affluent couples and would be eliminated for those with incomes over $130,000 a year. The
credit would be phased out for individuals with incomes from $75,000 to $95,000.

In a description of the proposal, the White House says: "The flat $1,000 credit would be given on the basis of a
certified need for long-term care, rather than expenses for long-term care. This means that families and people
with chronic illness or disability do not have to collect and submit receipts for paid home health care" or other
expenses.

Administration officials said the proposals recognized the value and costs of informal, unpaid long-term care
provided by relatives. If, for example, a man has a stroke and his wife takes time off from work to care for him,
she would not necessarily have a receipt to show her reduced hours of work or the time spent bathing and
feeding her husband. But the family might qualify for the tax credit.