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Biotech / Medical : VD's Model Portfolio & Discussion Thread -- Ignore unavailable to you. Want to Upgrade?


To: Vector1 who wrote (6223)1/5/1999 9:48:00 AM
From: Biomaven  Read Replies (3) | Respond to of 9719
 
VI,

The equity line is underwritten by that well known financier "major international bank." <G>. I guess they'll have to disclose the name when they actually take down any of the line - don't know why they are being coy.

IR is sending me a packet of more info on RFS 2000. There's not much publically available that I could find, although there are some interesting Stehlin patents around.

As to comparison with Gemzar, I can't believe the FDA would refuse approval if it does better than Gemzar. I don't think 5-FU is even approved for pancreatic cancer, so it's hard for the FDA to require a comparison. Anyhow, even a 5FU, adriamycin and mitomycin cocktail "did not contribute to life prolongation" although it did slow tumor growth some. The bar is very low here, and rightly so.

Like MGI-114, RFS-2000 did very well in mice:

asco.org

However, there seems to be a difference in how some of these compounds are metabolized in mice and people - the lactone ring opens much more quickly in people, which apparently kills efficacy. Unclear how RFS-2000 does in this regard.

What do you make of their "Extra" stuff?

As you say, a very strange company. I bought some anyway at around 6 1/2, and it's up nicely, although I have no idea why. <G>

Peter