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To: Webster who wrote (20806)1/5/1999 9:46:00 AM
From: Jon Koplik  Read Replies (1) | Respond to of 152472
 
(wacko) O.T. - psychiatric pharmaceuticals for dogs !

January 5, 1999

When It Looks Like a Dog's Life, Novartis
May Help With a Canine Antidepressant

By ELYSE TANOUYE
Staff Reporter of THE WALL STREET JOURNAL

There are no bad dogs, just sad ones.

That may be the new diagnosis pet owners will get when they bring their
neurotic dogs to see veterinarians, who will soon be able to prescribe an
antidepressant for old Fido. Novartis AG's U.S. animal-health unit received
U.S. Food and Drug Administration approval late last month to sell a
meat-flavored antidepressant pill for dogs suffering from "separation anxiety."
It's one of a number of drugs companies are developing to treat behavioral
problems in pets.

The drug, dubbed Clomicalm in its veterinary-use form, is an old
antidepressant called Anafranil, which has long been used to treat
obsessive-compulsive disorder in humans. Veterinarians have prescribed the
human drug for dogs, but by conducting clinical trials and receiving FDA
approval, Switzerland's Novartis can now directly promote the drug to
veterinarians and pet owners for use in dogs.

The drug is approved specifically for separation anxiety-behavior problems
such as destroying furniture, howling or inappropriate elimination that can
appear when the owner is away. Novartis says 14% of dogs -- about seven
million pets in the U.S. -- exhibit one or more signs of separation anxiety.

"Some owners think the pet is doing that out of spite, but they're really
suffering, experiencing a lot of anxiety" when the owner leaves, says G.C.
Ritchie, Clomicalm's product manager.

The company plans a big marketing campaign aimed at convincing pet owners
to take their errant dogs in to see the vet. A multimillion dollar consumer radio
and print advertising campaign will begin in February, with ads in such
magazines as Parade, Reader's Digest, and People. The advertising will stress
to pet owners that their dogs are suffering and need to see a veterinarian. One
ad will show a forlorn-looking dog with the phrase, "Some dogs just hate to be
alone." The ads will emphasize that Clomicalm won't alter a dog's personality
but could help it learn new, more positive forms of behavior.

The company also plans an extensive promotional campaign to veterinarians,
including a big splash this weekend at a veterinary convention in Orlando, Fla.
In addition, the vets will receive materials in the mail, and receive training at
dinner meetings, says Alice Coram, a Novartis animal-health unit
communications manager. Veterinarians will sell the medication directly.

The drug's cost is relatively high -- $1 a day for the minimum treatment length
of two to three months. But, said Ms. Coram, "When you consider the
problems some dogs can cause and the suffering they go through ... we don't
see [the cost] as a hurdle at all." She added that some pet-behavior specialists
have reported that their clients sometimes have thousands of dollars in damage
caused by anxious dogs.

Stephen F. Sundlof, the FDA head of veterinary medicines, said that behavioral
problems are particularly frustrating for owners, but "veterinarians haven't had
a lot of the tools that their human counterparts have had to address these very
complex issues, so having products like this available gives vets a lot better
chance of getting desirable results."

He noted that the drug is supposed to be taken along with behavioral therapy.
In addition, the drug's labeling warns that Clomicalm shouldn't be used with
certain other drugs, most of which have presented problems in humans.

Will the doggie antidepressant be overused or abused, as some people believe
occurs with humans? Novartis's Ms. Coram said, ''There's always concern in
that area, but we feel like we're doing everything we can to make sure it's used
properly.''

Copyright © 1999 Dow Jones & Company, Inc. All Rights Reserved.