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To: scaram(o)uche who wrote (368)	1/7/1999 3:34:00 AM
From: Mike McFarland	Respond to of 1073

Bayer sure does seem to be committed to asthma If you have the time to give me a few clues, I'd like to look into that. As you may remember one of the reasons I bought Ariad was because of some blurb they had on their website or in a press release regarding Asthma--what was it, mast cells and signal transduction, I forget. The idea was to not block any one mediator, but stop the whole cascade at the source. I suppose IMNX is the furthest along, aren't they in a phase three with some sort of a IL-4 blocker? It's funny, I'd love to have been in a phase III (last study I was in I got the placebo and my veins stabbed thirty times, ha ha) but even though IMNX is just ten miles away, I don't remember seeing anything about the UW med center needing volunteers at the Asthma and allergy center...of course I am beginning to fear needles, so that's part of it. Here is my little asthma story from today. I'm a daysleeper for a couple weeks while on graveyard shifts, so before setting out skiing today I slept in pretty late. Didn't hit the trail til noon, didn't get to the ridgetop til 3. Anyway, to make a long story short for a change, I had to go fast to get back before sunset and overdid it I guess (exercise induced asthma). Was a little tough for a few hours, coughed up some stuff etc. Anyway, a question-- what is the stuff I cough up sometimes? I mean, there is no allergic mediator, the atmosphere where I was skiing was as pure as can be, no dust no pollen, nothing (and sky was freaking blue, glorious...you should have been there!) I will ask the nurse practitioner at my HMO tomorrow if I am allergic to myself, heh heh. --MM

To: scaram(o)uche who wrote (368)	1/7/1999 4:31:00 AM
From: Henry Niman	Read Replies (1) \| Respond to of 1073

Rick, Monoclonals began coming out of Cambridge in 1975. I didn't think that USC got rolling with the technology until the early 80's. Were there USC publications using hybridomas before 1982?

To: scaram(o)uche who wrote (368)	1/7/1999 6:12:00 PM
From: EZLibra	Respond to of 1073

Hi Rick. A lot of learned people have doubts about the practicality of inducing localized thrombosis in humans. Don't they have the same doubts about Folkmanlike projects? From acorns grow... Thanks for the history on Phil Thorpe and deglycosolated ricin a chain. As I remember he was trying to poison the vessel but the potential for liver toxicity was too great. About a year ago he was causing the thrombosis with IgM abs but of course they were too large and the 1% production yield was causing problems. Now he's using IgG abs (96% yield) and results are promising. He expects to determine the ab for the clinic this year. Still it's a big and expensive project so we shareholders expect TCLN to license it off to Big Pharma. TNT is still our holy grail. Thanks for listening. Regards, -Davis