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To: Taki who wrote (3193)1/14/1999 4:23:00 PM
From: MoneyMade  Read Replies (1) | Respond to of 15987
 
CYTL shares rocket on HIV vaccine
data

NEW YORK, Jan 14 (Reuters) - Shares of Cytel Corp. more
than tripled in heavy trading Thursday after a Cytel subsidiary said initial data suggested a vaccine it
is developing could hold promise for controlling HIV infection.

Shares of Cytel jumped $5.75 to $7.75, making the stock one of the leading winners on the
Nasdaq stock market.

A scientist from Epimmune Inc. told a medical conference in Keystone, Colo., that two separate
trials of epitope-based vaccines in macaque monkeys and mice had yielded strong enough results
that they would be pursued.

In the first study, vaccinated monkeys showed strong immune system responses against an HIV-like
virus they were infected with. The monkeys were injected with a virulent strain of SIV, simian
immunodeficiency virus. The immune system responses are called CTL, for cytotoxic T-cell.

The vaccinated monkeys also showed a quicker immune response when they were infected with the
virus.

The mouse study showed that Epimmune could also develop a vaccine to work against several
different strains of HIV in a single vaccination. The mice showed CTL responses to each of the
different epitopes, Epimmune said.

Epimmune has struck a deal with G.D. Searle & Co., part of Monsanto Co. (NYSE:MTC - news),
to develop immune-stimulating products for the treatment of cancer.

Epimmune, a majority-owned subsidiary of Cytel, was not immediately available for further
comment.