To: Jenna who wrote (23232 ) 1/28/1999 11:50:00 AM From: j g cordes Respond to of 120523
HIV.. at 2 1/2 > 9/16. Herpes simplex is one of the world's most sought after cures. If this is a gain over Zovirax and some other anti-virals then this is significant. Article : "Herpes Vaccine Effective in Animals VIENNA, Va., Jan. 28 /PRNewswire/ -- In a study published in the latest issue of Vaccine, researchers at CEL-SCI CORPORATION (Amex: HIV, Berlin Stock Exchange: LSR) and Dr. Kenneth S. Rosenthal of Northeastern Ohio Universities College of Medicine (NEOUCOM), Rootstown, Ohio, demonstrated increased survival in mice after challenge with the herpes simplex virus. The immunizations allowed the animals to fight the infection much more quickly and effectively, resulting in reduced symptoms and mortality. Dr. Rosenthal said, ''It is significant to note that this protection appears to be due solely to cellular (e.g., T-Cell) immune response. We were not able to find antibodies to the vaccines in the animals.'' These new vaccines are based upon CEL-SCI's patented L.E.A.P.S.(TM) (Ligand Epitope Antigen Presentation System) technology. They consist of two protein pieces (peptides). The first is a copy of a small portion of a herpes simplex virus protein and the second is a T-cell binding ligand. The combination of these two peptides is a herpes simplex L.E.A.P.S. vaccine. The T-cell binding ligand increases the effectiveness of the vaccine by directing the immune response in a way most likely to eliminate or control the disease, which, in the case of herpes simplex, is thought to be the cellular immune response. The viral protein (in the form of a peptide) given without the T- cell binding ligand accelerated disease progression and mortality, while the addition of the T-cell binding ligand made the viral protein protective. Thursday January 28, 8:31 am Eastern Time Company Press Release SOURCE: CEL-SCI Corporation"