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Biotech / Medical : Ligand (LGND) Breakout! -- Ignore unavailable to you. Want to Upgrade?

To: bob zagorin who wrote (27853)	2/5/1999 6:23:00 AM
From: Henry Niman	Respond to of 32384

Sounds like the "delay" to get the labeling worked out was well worth the wait.

To: bob zagorin who wrote (27853)	2/5/1999 6:58:00 AM
From: Henry Niman	Respond to of 32384

Speaking of Panretin, here's a report that Panretin (9-cis retinoic acid) and Avandia (BRL49653) synergize to suppress leukemia (cell line) growth: Biochem Biophys Res Commun 1998 Oct 29;251(3):842-8 Induction of PPARgamma1 expression in human THP-1 monocytic leukemia cells by 9-cis-retinoic acid is associated with cellular growth suppression. Zhu L, Gong B, Bisgaier CL, Aviram M, Newton RS Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, 2800 Plymouth Road, Ann Arbor, Michigan, 48105, USA. 9-cis-Retinoic acid (RA) and peroxisome proliferator activated receptor gamma (PPARgamma) regulates cellular growth and differentiation. In THP-1 cells, a human monocytic leukemia cell line, RA markedly induced PPARgamma1 RNA, nuclear PPARgamma1 protein and suppressed cell growth. The PPARgamma ligand, BRL49653 enhanced RA's growth suppression ability. With BRL49653 alone, THP-1 cell growth was only marginally suppressed. Cell cycle analysis revealed the G1 phase cell population was significantly increased when cells were treated with both ligands. RA induced growth suppression did not differentiate the THP-1 cells to macrophages. Phorbol ester (PMA) induced differentiation of cells to macrophage also induced PPARgamma1 expression, however when RA is given either simultaneously or sequentially to these cells, no further increase in expression of the nuclear receptor was observed. Overall, these data suggest RA induction of PPARgamma1 may block cell growth and may have application for the treatment of proliferative diseases. Copyright 1998 Academic Press. PMID: 9790997, UI: 99008912

To: bob zagorin who wrote (27853)	2/5/1999 9:11:00 AM
From: Roland Batson	Read Replies (1) \| Respond to of 32384

Bob, Would you please explain to me in greater detail but more laymen's term what this abstract/report is saying and include as well the short to medium term (future) significance this may have on my LT (so far) position in LGND? Thanks, Roland To: bob zagorin (27853 ) From: Henry Niman Friday, Feb 5 1999 6:57AM ET Reply # of 27856 Speaking of Panretin, here's a report that Panretin (9-cis retinoic acid) and Avandia (BRL49653) synergize to suppress leukemia (cell line) growth: Biochem Biophys Res Commun 1998 Oct 29;251(3):842-8 Induction of PPARgamma1 expression in human THP-1 monocytic leukemia cells by 9-cis-retinoic acid is associated with cellular growth suppression. Zhu L, Gong B, Bisgaier CL, Aviram M, Newton RS Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, 2800 Plymouth Road, Ann Arbor, Michigan, 48105, USA. 9-cis-Retinoic acid (RA) and peroxisome proliferator activated receptor gamma (PPARgamma) regulates cellular growth and differentiation. In THP-1 cells, a human monocytic leukemia cell line, RA markedly induced PPARgamma1 RNA, nuclear PPARgamma1 protein and suppressed cell growth. The PPARgamma ligand, BRL49653 enhanced RA's growth suppression ability. With BRL49653 alone, THP-1 cell growth was only marginally suppressed. Cell cycle analysis revealed the G1 phase cell population was significantly increased when cells were treated with both ligands. RA induced growth suppression did not differentiate the THP-1 cells to macrophages. Phorbol ester (PMA) induced differentiation of cells to macrophage also induced PPARgamma1 expression, however when RA is given either simultaneously or sequentially to these cells, no further increase in expression of the nuclear receptor was observed. Overall, these data suggest RA induction of PPARgamma1 may block cell growth and may have application for the treatment of proliferative diseases. Copyright 1998 Academic Press. PMID: 9790997, UI: 99008912