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Biotech / Medical : XOMA. Bull or Bear? -- Ignore unavailable to you. Want to Upgrade?

To: opalapril who wrote (8636)	2/7/1999 1:23:00 AM
From: aknahow	Read Replies (2) \| Respond to of 17367

If XOMA drives you to drink, BPI might be a solution. Journal of Hepatology Volume 26 - issue 3 - page 567 - 573 © EASL Decreased endotoxin-binding capacity of whole blood in patients with alcoholic liver disease Christian Schäfer, Bernd Greiner, Jörg Landig, Elke Feil, Elke Tatjana Schütz, J. Christian Bode and ChristianeBode Background/Aims:The proinflammatory effects of endotoxemia, which is often observed in alcohol-abusing patients with various degrees of liver disease, may be modulated by changes in the concentration of endotoxin binding factors. Therefore, the plasma endotoxin concentration and the overall endotoxin binding capacity of whole blood were measured in these patients. Methods:Patients with minor (A1; n=27), more pronounced (A2; n=13), cirrhotic alcoholic liver disease (A3; n=18), and non-alcoholic cirrhosis (NC; n=6), and 15 healthy control persons (HC) were included in the study. Endotoxin plasma levels were determined using a standardized limulus assay. A modified assay was applied to additionally detect tightly bound endotoxin. To measure the endotoxin-binding capacity, aliquots of whole blood were incubated with serial dilutions of endotoxin, supernatants were obtained, and endotoxin retrieval was estimated by addition of limulus lysate, followed by photometric measurement of the maximal reaction velocity (dODmax). Endotoxin binding capacity equals the endotoxin concentration at which dODmax reaches a predefined threshold. Results:All groups of alcohol abusers had significantly elevated endotoxin plasma levels with a considerable portion of &rsquor;bound' endotoxin. Conversely, the endotoxin binding capacity was markedly diminished, mainly in patients with more advanced liver disease (A1: 85.8% of the control value ]non-significant vs. controls[; A2: 25.4% ]p<0.05[; A3: 43.6% ]p<0.02[, NC: 43.2%). Conclusions:The endotoxin-binding capacity is diminished in patients with alcoholic and non-alcoholic cirrhosis, as well as in less advanced alcoholic liver disease. Reduced endotoxin binding may contribute to the adverse effects of endotoxemia. This post is made for entertainment value only. Minimal value at that. Do your own drinking do not rely on what others do. Neither Neuprex or BPI are being ivestigated by XOMA or Bob for any use related to the above condition.