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Biotech / Medical : XOMA. Bull or Bear? -- Ignore unavailable to you. Want to Upgrade?


To: Bluegreen who wrote (8653)2/9/1999 11:57:00 AM
From: aknahow  Read Replies (1) | Respond to of 17367
 
Another non novel patent.

United States Patent
5,869,619
Studnicka
Feb. 9, 1999

Modified antibody variable domains

Abstract

Methods are described for identifying the amino acid residues of an antibody variable domain which may be modified
without diminishing the native affinity of the domain for antigen while reducing its immunogenicity with respect to a
heterologous species and for preparing so modified antibody variable domains which are useful for administration to
heterologous species. Antibody variable regions prepared by the methods of the invention are also described.