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Biotech / Medical : Gene therapy -- Ignore unavailable to you. Want to Upgrade?

To: Mike McFarland who wrote (12)	2/12/1999 3:40:00 PM
From: Mike McFarland	Read Replies (1) \| Respond to of 319

Okay, here is the post. I had to try and find a daytrade on this first, but no luck ...thanks for feedback folks, you know who you are. It took me awhile to get here, but here is today's PR from EurekaAlert! eurekalert.org "This double deletion makes the virus 'quieter' to the immune system, and allows it to deliver the transgene unnoticed," Amalfitano said. So this is pretty big news I think. Apparently knocking out a few genes first is old news...because I found this (note, a java script will bomb...just try to ignore it) brunel.ac.uk Adenoviruses are potentially oncogenic due to the presence of the genes E1A, E1B (transcriptional regulators necessary for viral DNA replication) and E3 which therefore have to be deleted during vector construction (but this will require the use of a helper cell line); the capacity to insert foreign DNA is around 7.5 kbp. More recent adenovirus-based vectors have in addition a mutation in the E2A gene. And from CEGE we have this... Cell Genesys' proprietary second-generation adenoviral vector has been modified to enhance its clinical utility by deleting the E1 and E4 gene regions of the adenovirus. So the question becomes what stocks might react to the news... my list includes TRGNY ONXX CLTX CEGE at around 3:00 EST this afternoon, CEGE and AVGN showed a pulse at the same time...but nothing conclusive. EST is not Expressed Sequence Tags, heheh. I did not do a trade, for a moment I was tempted to get rid of a little Ariad, but decided against it. That is a full position that just sits til something happens...I have other money with which I can try and chase another Gene Therapy stock at a later date. --Mike