To: BRAVEHEART who wrote (446 ) 2/18/1999 9:06:00 AM From: Apache Indian Read Replies (3) | Respond to of 1494
Mr. Paul Friemans reply (pretty comforting I must say) Dear Mr. ________: Thank you for your thoughtful inquiry concerning Neurobiological Technologies, Inc. (NTI) I am sure that as a longer-term investor you have experienced a great deal of frustration with our stock price. The questions you ask regarding financing can really be put into a nutshell as follows: The credibility of NTI has never truly been restored in the investors' minds following early announcements of the lack of results from a CRF trial in rheumatoid arthritis. The environment for small cap companies (under $300 million market cap) is quite difficult in the biotechnology field. Sophisticated investors have come to realize that it takes a biotechnology company up to 12 years to develop a drug, the same as large pharmaceutical companies. As a consequence, people are less and less willing to take the risk of investing in small, under-capitalized companies whose potential tends to be in the longer term. This is not unique to NTI but is endemic in the industry. I don't intend to close this company down since we have Memantine, a product which I truly believe will see the light of day in a relatively short period of time, i.e., between the next one and three years. The product has behaved well in our hands and in our corporate partner's, Merz + Co. GmbH & Co., who is in late Phase III trials for senile dementia and Alzheimer's disease. At this point in time, Merz and NTI are negotiating a major global marketing agreement with a large pharmaceutical company. I believe there is a good opportunity for such a relationship in the next few months. Such a relationship would trigger seven-figure payments to our company and a subsequent substantial stream of income through milestone payments and royalties. At this point in time, I am working diligently to secure enough financing to bridge us to that point in time and I am confident that we will succeed. I would be happy to speak with you directly if you care to call me at 510-215-8000. Thank you for sticking with us as a shareholder for the past three years. Sincerely, Paul E. Freiman