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Biotech / Medical : XOMA. Bull or Bear? -- Ignore unavailable to you. Want to Upgrade?

To: Robert K. who wrote (8795)	2/20/1999 10:39:00 PM
From: Bluegreen	Read Replies (2) \| Respond to of 17367

Alright guys enough of the monkey business. Chord with me now on LBP patents. BTW George how do you know HMOs don't cover primates?

To: Robert K. who wrote (8795)	2/21/1999 9:17:00 AM
From: Robert K.	Respond to of 17367

Lines 1,2,3,4,> 3 domains, 3 functions, why would they do this? What does bpi do? What does lbp do? What does cd14 do? >DUH.................(from patent)>....... What is claimed is: 1. A lipopolysaccharide binding protein (LBP) derivative hybrid protein consisting of an LBP amino acid sequence selected from within the amino-terminal half of LBP wherein at least a portion of the LBP sequences SEQ ID NO:20, SEQ ID NO:21, or SEQ ID NO:22 is respectively replaced with at least a portion effective for endotoxin binding of the bactericidal/permeability-increasing (BPI) sequences SEQ ID NO:17, SEQ ID NO:18, or SEQ ID NO:19. 2. The hybrid protein according to claim 1 which is LBP(1-87)/BPI(88-100)/LBP(101-197) (SEQ ID NO:51). 3. The hybrid protein according to claim 1 which is LBP(1-146)/BPI(148-161)/LBP(160-197) (SEQ ID NO:52). 4. The hybrid protein according to claim 1 which is LBP(1-87)/BPI(88-100)/LBP(101-146)/BPI(148-161)/LBP(160-197) (SEQ ID NO:53). 5. A DNA sequence consisting of a DNA encoding an LBP derivative hybrid protein according to claim 1. 6. A DNA vector comprising the DNA sequence according to claim 5. 7. A host cell stably transformed or transfected with a DNA sequence according to claim 5 in a manner allowing expression in the host cell of the protein encoded thereby. 8. A pharmaceutical composition comprising an LBP derivative hybrid protein according to claim 1 and a pharmaceutically acceptable diluent, adjuvant or carrier. 9. A method of treating a gram-negative bacterial infection comprising administering an LBP derivative hybrid protein of claim 1. 10. The method of claim 9 wherein the LBP derivative hybrid protein is administered at a dosage of from about 0.1 mg/kg to about 100 mg/kg of body weight.