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Biotech / Medical : PFE (Pfizer) How high will it go? -- Ignore unavailable to you. Want to Upgrade?


To: BigKNY3 who wrote (7094)2/25/1999 1:37:00 PM
From: Anthony Wong  Respond to of 9523
 
Tyson & Hartman: Victims of Drug?
Wednesday, February 24, 1999

By MARTY ROSEN
Daily News Staff Writer

ike Tyson tossed a television after going off the drug Zoloft,
and Phil Hartman's wife had taken the anti-depressant
before killing the actor and herself.

But psychiatrists say depression — and not a drug-related
reaction — likely caused their violent behavior.

"A certain percentage of depressed patients
have anger attacks. Not all of them throw
television sets, but they do have outbursts,"
said Dr. Jan Fawcett, psychiatry chairwoman
at Rush Medical Center in Chicago. "When
you stop a medicine, especially if you stop it
suddenly in the middle of a depressive
episode, the depression will return."

The family of Phil Hartman, the "Saturday
Night Live" star fatally shot last year by his
wife, Brynn, said they plan to sue Pfizer, the
pharmaceutical giant that makes the anti-depressant.

They say the Zoloft may have triggered Brynn Hartman's
murderous rage.

Tyson, who is serving a one-year sentence for a road rage attack
on two motorists, hurled a television set in a Maryland prison last
week — reportedly two days after a prison doctor stopped giving
him Zoloft.

"There's no link in any of the medical literature related to violent
behavior and Zoloft," said Pfizer spokesman Andy McCormick,
who noted that more than 85 million Zoloft prescriptions have
been written since the drug went on the market in 1992.

"It's really helping patients with depression," he said. "The patient
needs to stay on the therapy to have the proper effect."

McCormick said a murder defendant in a Florida trial also tried to
blame his behavior on the drug, but a jury rejected the argument
and found him guilty.

Psychiatrists say it would take scientific clinical trials to prove a
link between a drug and certain behavior — and anecdotal
evidence like the Tyson and Hartman cases doesn't cut it.

"It's a complex and difficult procedure. It takes time," said Dr.
Michael Aranoff, a psychiatrist at NYU Medical Center.

Aranoff blamed the legal system's search for a quick answer to
tough questions for criticism of the popular drug.

"We've got a legal and adversarial process looking for a quick
claim and deep pockets," he said.

mostnewyork.com



To: BigKNY3 who wrote (7094)2/25/1999 1:48:00 PM
From: Anthony Wong  Respond to of 9523
 
BOSTON CAPITAL Lowering the boom
By Steven Syre and Charles Stein, Globe Staff, 02/25/99

If philosopher George Santayana was right, and those who forget the
past are doomed to repeat it, then this may be a good time for a
history lesson. Set the wayback machine for the early 1990s, Sherman.
We're going back to the biotechnology boom on Wall Street, a
development with some eerie parallels to the current mania for Internet
stocks. Notes Katherine Kirk, an investment banker with Hambrecht &
Quist in Boston: ''Investors are in love again.''

Biotechnology stocks took off in 1990 when one of the industry's leaders,
Amgen Inc., produced the first biotech blockbuster, a key drug for kidney
dialysis patients. For investors the message was clear: Biotech was ready
to move from the laboratory to the marketplace. Diseases would be cured;
money would be made. Hardly any biotech companies were making
money at the time, but that didn't matter. Profits took a back seat to
potential.

Amgen's stock price rocketed from 7 to 78 in a short period of time. In
1991, Fidelity's Select Biotechnology fund climbed an astounding 99
percent and its assets ballooned from $70 million to $1.1 billion in less than
two years. It looked as if the sky was the limit.

Only it wasn't. In early 1992 the stocks started to tumble as investors
questioned some of their early assumptions. And in the spring of that year,
when the US Food and Drug Administration refused to approve drugs
from two of the highest-flying biotech companies, the rout was on. The
stock price of Centocor Inc., one of the spurned companies, fell from 60
to under 10.

Biotechnology didn't disappear. A handful of companies, including Amgen,
have gone on to become large, profitable businesses.

But investors never made the kind of money they dreamed about in those
heady days. The Fidelity biotech fund, for instance, has less money in it
today than it did at the peak in 1991. Hambrecht & Quist's own biotech
index is no higher than it was back then.

''It's as if we had a wild New Year's Eve Party and the hangover lasted
years,'' says Brian Stack, portfolio manager of MFS New Discovery fund.

Investment pros who lived through both periods will tell you there are
important differences between biotechnology and the Internet. Biotech's
progress in bringing products to market was agonizingly slow; the Internet
seems to grow at lightspeed. Biotech had the potential to change medicine;
the Internet may yet change every business it touches.

But there are parallels between the two booms as well, say money
managers. And perhaps a few cautionary lessons too. What can we learn
from studying the biotechnology bubble?

1. It's hard to pick the ultimate winners at the beginning.

Imagine you are a farmer planting seeds in the spring. Can you say, at that
point, which plants will grow tall and straight and which will never sprout?
An investor evaluating companies in an emerging industry is in much the
same position.

''You are dealing with a new technology and no one knows how the story
will play out,'' says David Stone, who followed biotechnology stocks for
the Boston office of Cowen & Co.

Amgen and Centocor were both early biotech leaders. One soared, the
other stumbled, at least until recently.

And Biogen Inc., a Cambridge company that has been a Wall Street
favorite, didn't come on the radar screen until 1996.

2. Sometimes it's even hard to know who the players are.

Investors assumed that biotechnology was a world unto itself. They were
wrong. At the same time biotech companies were busy in their labs, the
major drug companies were even busier working on blockbuster drugs for
the future. With the benefit of hindsight, investors who believed in the
promise of biotech should have been investing in companies like Merck &
Co. and Pfizer Inc.

Similarly, the Internet is viewed today as a distinct field with distinct
companies. But who is to say that the ultimate winners in the Internet
competition won't be established names like Wal-Mart or IBM rather than
Amazon.com and Yahoo?

3. Euphoria has a way of blinding people to risk.

In their enthusiasm for biotech stocks, investors failed to appreciate how
long it would take to turn good ideas into marketable products. With the
Internet, the risk may be just the opposite. Because there are practically no
barriers to entry, just about anyone can jump into the Internet business
overnight.

''We're dealing with a much fiercer competitive landscape,'' says Kirk of
Hambrecht & Quist. In such a world, she says, competitive advantage can
vanish as quickly as it appears. Which leads to an obvious question: Is that
risk built into the price of Internet stocks?

4. Promise is not the same thing as profit.

Thomas O'Neill, chief investment officer at Fleet Financial Group Inc.,
says it was hard not to be excited by the potential of biotechnology.

''You were talking about curing diseases,'' he recalls. ''These were exciting
things.''

The Internet has the same kind of buzz about it. Like biotechnology, it
could change the way we live our lives. But eventually that excitement has
to find its way to the bottom line. Companies don't have to make money in
the early days. New firms can have valuations that look preposterous on
the surface.

But down the road investors need to see a real return. Otherwise, as the
biotech boom demonstrated, soaring stock prices can come back to earth
in a hurry.

Red Herring

Matthew Nestor has been named director of the state securities division by
Secretary of the Commonwealth William Galvin.

In his new job Nestor will manage the staff that regulates the offer and sale
of securities. Nestor previously was chief of enforcement in the securities
division.

''Matt Nestor is a respected figure in the fight against investment fraud in
Massachusetts and nationwide,'' said Galvin.

Nestor is a graduate of Boston College Law School.

Steven Syre (929-2918) and Charles Stein (929-2922) can also be
reached by e-mail at boscap@globe.com.

This story ran on page D01 of the Boston Globe on 02/25/99.
© Copyright 1999 Globe Newspaper Company.

boston.com



To: BigKNY3 who wrote (7094)2/25/1999 5:31:00 PM
From: Anthony Wong  Read Replies (1) | Respond to of 9523
 
02/25 15:25 IMS HEALTH Reports 164,459 Celebrex Prescriptions Dispensed in Third Week of February

IMS HEALTH Reports 164,459 Celebrex
Prescriptions Dispensed in Third Week of February

LONDON--(BW HealthWire)--Feb. 25, 1999--
Mail Order Prescriptions Rise 43 Percent
IMS HEALTH (NYSE:RX) today reported that for the week ending Feb.
19, 164,459 total prescriptions were dispensed for Celebrex in the
U.S. This represents a 30 percent increase in prescriptions dispensed
compared to the previous week. Celebrex is the first in a new class of
drugs called Cox-2 inhibitors, used to treat the symptoms of
rheumatoid arthritis as well as osteoarthritis. IMS HEALTH's regular
weekly prescription activity report covering the week ending Feb. 19
becomes available on Monday, March 1. IMS HEALTH is the world's
leading provider of information solutions to the pharmaceutical and
healthcare industries.

According to IMS HEALTH, Celebrex mail-order prescriptions
totaled 6,664 for the week ending Feb. 19, compared to the 4,724
mail-order prescriptions reported the previous week, an increase of 43
percent.

For the week ending Feb. 12, the majority of physicians
dispensing Celebrex were Primary Care Physicians, who wrote 49.8
percent of Celebrex prescriptions. Orthopedic Surgeons wrote 20,840
Celebrex prescriptions, representing 17 percent of the total
prescriptions written. Rheumatologists wrote 14 percent of
prescriptions for the week, dispensing 16,400 prescriptions.

IMS HEALTH's weekly prescription tracking service provides
comprehensive coverage of three U.S. retail channels -- chain drug
stores, independent pharmacies and food stores with pharmacies -- and
includes cash and Medicaid prescriptions as well as third-party
reimbursement. The service also provides unique access to mail-order
prescriptions, making it the most complete market tracking service
covering the U.S. pharmaceutical industry.

IMS HEALTH is the world's leading provider of information
solutions to the pharmaceutical and healthcare industries. With more
than $1.2 billion in 1998 revenue, IMS HEALTH operates in over 90
countries. IMS HEALTH is the largest pharmaceutical manufacturer
information partner, with over 40 years' experience in the industry.
Key products and services integral to customer day-to-day operations
include: market research for prescription and over-the-counter
pharmaceutical products; sales management information to optimize
sales force productivity; technology enabled selling solutions for
sales and marketing decision-making; and technology systems and
information services that support managed care organizations.
Additional information and previous press releases are available at
IMS HEALTH's web site: imshealth.com.

--30--jd/ny*

CONTACT: Nancy Duckwitz (U.S)
(610) 834-5338
or
Michael Gury (U.K.)
44-171-393-5864

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