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Biotech / Medical : T/FIF Portfolio -- Ignore unavailable to you. Want to Upgrade?

To: Pseudo Biologist who wrote (626)	2/27/1999 8:19:00 PM
From: scaram(o)uche	Respond to of 1073

PB: We ain't got no topic. I hate third-tiers. ;-) >> show that anti-FcgammaRI mAbs are promising vaccine adjuvants << Now that I believe. Of course, I also feel that you don't have to get fancy and that a little sub-clinical IL-1 or TNF will also do the trick. Correct.... GM-CSF. However, it just belies the lack of rationale behind the original work..... MAbs are not, IMO, going to "target" cells. That is, I feel that activation is worthwhile, but I just can't see a molecule dragging a cell to a tumor. Afraid you have to get the cell to the tumor independent of an antibody. And, I feel the same about the FcAlpha stuff..... activation is a worthwhile goal, but bispecifics just don't make sense to me. They never have made sense to me, and I was up to my eyeballs in early experiments that have made me very wary of data presented by MEDX. Half-life.... good point. I like companies that are using multimers like IMGN or agonist/antagonist antibodies like BTRN is doing. I pick BTRN because the CD2 data doesn't make sense to me if it's anything other than binding two CD2 molecules together in such a fashion that the intracelluar domains signal "die" to the cell in the presence of a CD3-related signal. I differentiate this from a passive mechanism like I assign to anti-CD40L, where Fabs should work fine????? Please note.... odds are high that I'm full of it, as you must realize. But, you get nothing correct if you don't propose. Rick