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Biotech / Medical : VVUS: VIVUS INC. (NASDAQ) -- Ignore unavailable to you. Want to Upgrade?

To: Zebra 365 who wrote (19174)	3/2/1999 12:57:00 AM
From: VLAD	Read Replies (1) \| Respond to of 23519

Zebra, Can you tell us why if grapefruit juice is such a potent inhibitor of the enzyme system that is responsible for sildenafil metabolism that this rather important fact is not mentioned on the drug insert? Down here in South Florida we have tons of elderly people. We also have an abundance of orange and grapefruit trees which grow in the front and back yards of many of these elderly people. In fact I have been eating fresh grapefruit off my friend's trees for the past 2 months. We have so many grapefruit that much of it doesn't even get picked and ends up rotting away. I would wager to say that there are a good number of elderly men here who take Viagra and drink grapefruit juice or eat grapefruit picked off their own tree and don't even know about this important fact. Is this ANOTHER example of the FDA protecting the public health as usual? Well then again these are the same people who say there is no clear evidence that there is a causal relationship between sildenafil use and sudden death from coronaries and it was probably just the stress of sex that caused all those heart attacks. LOL

To: Zebra 365 who wrote (19174)	3/2/1999 12:16:00 PM
From: DaiS	Read Replies (2) \| Respond to of 23519

Zebra, I'm not saying you were heavy, but you should take your fellow professionals to task, not berate poor laypersons who can only follow doctors advice <g> Have you actually read this?? news.bbc.co.uk newsfile.com Savings The practice is reported in Doctor newspaper. Dr David Delvin runs private psychosexual clinics in Cambridge and London. He confirmed he knew patients who carried out the practice. He said: "I do not recommend it myself but there is no doubt that lots of my commercially aware patients are doing this. "A number of shrewd chaps have spotted it works out a great deal cheaper if you are on 50mg to buy 100mg, which only costs a tiny bit more, and split it in two. However, there are dangers involved in doing this, he said. "It's just possible that the drug is not evenly distributed through the tablet and the side effects could be increased or it won't work properly and the patient will be disappointed." Dr Douglas Savage is an impotence specialist and a GP in Doncaster. He told Doctor: "I am sure it's widespread. Patients are not at any increased danger but they may get more side-effects." Do you not think that Dr Devlin would be better advised counselling his patients on fatty meals or grapefruit juice? What are us punters supposed to think? The practice could reduce by 50% the revenue from viagra in the UK. If this occurs worldwide, the 7% would be substantially reduced. Is this of no consequence to Pfizer? I suspect cheaper viagra will not effect muse sales since it appears that cost is not a major factor in choice of therapy, rather effectiveness or side effects. If I started the "debate" let us finish it with the grave concern on the subject expressed so eloquently by Dr Devlin: "I had one patient who chopped up a Viagra tablet, when a bit went under the piano the dog ate it." DaiS PS Did you meet such doctors when you were in Brecon!?