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Biotech / Medical : Biogen -- Ignore unavailable to you. Want to Upgrade?


To: Harold Engstrom who wrote (894)3/2/1999 6:17:00 PM
From: Beltropolis Boy  Respond to of 1686
 
harold.

following is an excerpt from a lehman bro's sell-side piece a couple of weeks old. it's written after the inhale deal, and while it doesn't really bring anything new to the table, i thought you might like their perspective just the same.

note the disclaimer.

for what it's worth,
-chris.

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Headline: Biogen: Signs Deal for Pulmonary Delivery of Avonex
Author: C. A. Butler, PhD / S. Pandya 212-526-4410
Rating: 1
Company: BGEN
Rank (Old): 1-Buy
Rank (New): 1-Buy
Price: $90 3/8
52wk Range: $101-41
Price Target (Old): $110
Price Target (New): $110

Proj. 5yr EPS Grth: 20.0 %
P/E 1999; 2000 : 36.1X; 30.6X
Current Book Value: $9.30/sh
Debt-to-Capital: 7.6%
Disclosure(s): Lehman Brothers Inc. makes a market in the securities of this company.

* Biogen announced the signing of a collaboration with Inhale (INHL - 28 5/8, Venture 1) toward the development of pulmonary delivery for Avonex. Recall that Avonex is Biogen's drug for multiple sclerosis which recorded $395 million in sales last year.

* Under terms of the agreement, Inhale will receive up to $25 million in funding and milestone payments. Biogen will handle clinical trials and provide bulk material, while Inhale will provide expertise in manufacturing and inhalation devices.

* We believe that the up-front payment given to Inhale is approximately $1 million and thus not likely to impact our financial estimates for Biogen this year.

* We are encouraged by management's long-term vision and view this as a possible mechanism to enhance Avonex's competitive position.

* The underlying fundamentals at Biogen remain quite strong, as such, we are comfortable with our 1 Buy investment rating and our 12-month price target of $110.



To: Harold Engstrom who wrote (894)3/2/1999 9:48:00 PM
From: Y. Bob Ai  Read Replies (1) | Respond to of 1686
 
To all:

I read from Dow Jones news that "Avonex, Betaseron and Rebif all are forms of beta interferon." Could someone tell me what are the chemical differences among them?

Any comments will be welcome.

Bob Ai



To: Harold Engstrom who wrote (894)3/15/1999 11:14:00 AM
From: Beltropolis Boy  Read Replies (1) | Respond to of 1686
 
fwiw, biogen makes motley fool's daily double.

-----

DAILY DOUBLE
Monday, March 15, 1999

Biogen, Inc.
(Nasdaq: BGEN)
Website: biogen.com
Phone: 617-679-2000
Price (3/12/99): $110 3/16

HOW DID IT DOUBLE?

It wasn't too long ago that Biogen (Nasdaq: BGEN) was strictly a cooperative research firm. The company would research and develop new drugs, but would leave the marketing and distribution of its discoveries to other pharmaceutical companies. However, with Biogen's discovery of AVONEX, a treatment for multiple sclerosis (MS), the firm decided to switch gears, vertically expand, and become a fully integrated pharmaceutical company. Instead of sitting back and collecting royalties like it had in the past, Biogen created its own distribution network and is now actively selling its own products.

The new strategy has certainly paid off for the company thus far. AVONEX has been a smashing success since its release in 1996, and revenues at the company have more than doubled over the past two years. Profits and cash flow, not surprisingly, have also been positively affected by sales of the new drug. The company even produced enough extra cash to buy back 2 million of its own shares over the past year and a half, the first buyback the company had ever instituted.

With AVONEX sales continuing to post impressive growth, the company announced on February 22 that it intends to repurchase up to an additional 4 million shares of its stock. Also helping Biogen is the FDA's March 1 decision to limit sales of a potential competing drug. Serono Laboratories, a Swiss firm, did not clear the FDA's hurdle for selling Rebif, its own treatment for MS, in the U.S. With a would-be competitor out of the way, shares of Biogen have continued their skyward march.

While Biogen was sold down to as low as $41 3/4 in the late-summer panic of 1998, the stock's direction has been in essentially the same direction ever since -- up.

BUSINESS DESCRIPTION

Founded in 1978 and based in Cambridge, Massachusetts, Biogen is a biopharmaceutical company involved in the development, manufacturing, and marketing of drugs for human use. Many of the company's early discoveries, including alpha interferon and a hepatitis B vaccine, are distributed by larger pharmaceutical firms such as Schering-Plough (NYSE: SGP) and Merck (NYSE: MRK). However, these days, the company's strategy is to sell its discoveries itself.

At the moment, the sole drug sold exclusively by the company is AVONEX, currently the world's most-used treatment for multiple sclerosis. After receiving FDA approval for widespread distribution in 1996, the drug is now selling at a $500 million annual rate. In the last quarter, roughly 74% of Biogen's sales were thanks to AVONEX. The balance of sales came from royalties on the company's older products.

Biogen is a member of the S&P 400 MidCap index.

FINANCIAL FACTS

Income Statement
12-month sales: $557.6 million
12-month income: $138.7 million
12-month EPS: $1.80
Profit Margin: 24.9%
Market Cap: $8557.8 million

Balance Sheet
Cash: $516.9 million
Current Assets: $694.1 million
Total Assets: $924.7 million
Current Liabilities: $131.0 million
Long-term Debt: $71.0 million

Ratios
Price-to-earnings: 61.2
Price-to-sales: 15.3

HOW COULD YOU HAVE FOUND THIS DOUBLE?

One way to have found Biogen would be to look at the sales trend of AVONEX. The drug has seen increasing usage in each quarter since its release, a significant sign of how well AVONEX is regarded as a treatment for MS. Even if AVONEX was equally effective as other drugs on the market, its reduced dosing frequency (weekly versus every other day) remains an attractive attribute, especially for a class of drugs that needs to be injected intramuscularly. With early and strong acceptance of the product in the U.S., it would naturally follow that the rest of the world would eventually approve and start using the product. AVONEX is now prescribed twice as often as the next most popular MS treatment.

Another bullish signal was the company's ongoing share buyback. With the costs of developing AVONEX far in the past, the drug has been the proverbial cash cow. This has left Biogen with some extensive financial flexibility, allowing the company to keep its share count low. Seeing a company purchase its own shares is often a bullish sign.

Another factor worth considering was the company's winning the National Medal of Technology for 1998, among the nation's highest scientific honors.

WHERE TO FROM HERE?

While Biogen has had extreme success with AVONEX, the company remains essentially a one-cow farm. With nearly three-quarters of the company's sales coming from only one compound, concerns about product diversification are entirely prudent. However, Biogen's single cash cow is rather fat and healthy, and promises to be alive through at least 2003, when the patent on AVONEX runs out.

Four years left on the AVONEX patent still gives the company plenty of time to harvest the market, but successful clinical trials of drugs in Biogen's portfolio will be needed to sustain the current valuation through the next decade. The company currently has drugs in Phase II clinical trials for treating lupus, edema, and psoriasis. Additional applications of AVONEX are also being studied.

While smaller on an absolute basis than many of its peers, Biogen currently earmarks roughly 30% of its sales for research and development. This compares quite favorably to Pfizer's (NYSE: PFE) roughly 15% and Merck's 12%. Whether these expenditures yield a marketable drug is always a crapshoot, but the chances appear good that Biogen will add another cash cow to its barn over the next few years.

Biogen's entire industry group, pharmaceuticals, is also quite an attractive industry these days. With the FDA's recently streamlined drug approval process, companies can recoup their research expenses much quicker. Moreover, the faster approvals can result in more time to sell the drug under patent protection. (The patent time-clock starts ticking when the drug is discovered, not when it is approved for sale, so a fast approval is advantageous to the company's profits.) And with an aging population, demand for all types of drugs is going to continue to increase for the foreseeable future. The group in general, and Biogen in particular, may trade at premium valuations, but there are some extremely valid reasons why the companies have been bid up.

In the short term, continued expansion of AVONEX will drive Biogen's stock. There are currently 55,000 patients using AVONEX, and the company's CEO recently said that they expect to see more than 100,000 patients taking the drug over the next few years. Acceptance may also get another push if the company's efforts with Inhale (NYSE: INHL) produce a form of the drug that can be inhaled.

At 61 times trailing earnings, some of this future growth has obviously been priced into the stock already. Nevertheless, Biogen is worth keeping an eye on, especially if some of the drugs in the company's pipeline pass the FDA's phase III trials.

--Paul Larson
(TMFParlay@aol.com)

fool.com



To: Harold Engstrom who wrote (894)3/18/1999 1:10:00 PM
From: Beltropolis Boy  Respond to of 1686
 
***slightly OT***

must be nice to stay local.

-----

Boston Scientific soars on new CEO, FDA approvals
Reuters Story - March 18, 1999 11:44

BOSTON, March 18 (Reuters) - Shares of Boston Scientific Corp. climbed 15 percent early Thursday, boosted by news that Biogen Inc.'s former chief executive officer, James Tobin, would take that position at the medical device maker.

"Tobin has always been viewed as a straight-shooter," Hambrecht & Quist analyst Robert Faulkner said. "He's widely respected on the Street and he brings credibility that the company desperately needs."

At 11 a.m., EST, Boston Scientific was up 4-7/8 to 38-3/8 in heavy trading. It was the New York Stock Exchange's fifth most active issue.

In the last two days the U.S. Food and Drug Administration approved two Boston Scientific products, Faulkner added.

He said the products were not major ones but the approvals were an "indication that despite their earlier problems with the (U.S.) Justice Department, the FDA is continuing to review and in a timely way approve their systems."

The U.S. Justice Department is investigating the company for any changes it might have made to a coronary stent delivery system it launched last year after the Food and Drug Administration approved it on Aug. 12. Surgeons use the product to prop up and unclog weakened coronary arteries.

CS First Boston has already upgraded the company, which is introducing Tobin to analysts at a conference Thursday.



To: Harold Engstrom who wrote (894)3/19/1999 11:05:00 AM
From: Beltropolis Boy  Read Replies (1) | Respond to of 1686
 
Posted 3/19/99
Company Focus
Biogen converts healthy sales into surging stock
The biotech with multiple sclerosis therapies and a packed drug pipeline now offers investors a powerful side effect: Shares have swelled 206% since last year.

Investor
By George S. Mack

It's hard to hear the term genetic engineering without picturing all sorts of swamp creatures and killer tomatoes from Hollywood's B movies.

But one day in 1978, a group of not-so-mad visionaries got together in Geneva, Switzerland, to brainstorm a new kind of business that would tinker with DNA molecules -- the actual template of life. From that hopeful beginning, Nobel laureate biologists Phillip Sharp of the Massachusetts Institute of Technology and Walter Gilbert of Harvard University became the co-founders of Biogen (BGEN) and creators of a new industry with a single purpose: to create drug therapies for diseases then considered untreatable.

Suffering patients now are being treated by those new therapies. But Biogen investors also have been treated well in the 1990s, following a slow start as a public company in 1984. Since the beginning of this decade, the stock is up 1,216% -- almost double the advance of pharmaceutical powerhouses Warner-Lambert (WLA), Eli Lilly (LLY) and Merck (MRK). And during the last two years, it has even zipped past Pfizer (PFE), with a 206% gain since Jan. 1, 1998, alone.

Now some analysts believe Biogen might only be getting started. What's happening and what does the future hold? Let's take a look.

Treating multiple sclerosis
Biogen developed a variety of successful therapies and diagnostics that it licensed to bigger drug makers over its first few years, but it really hit the big time in 1996 when it launched Avonex, the world's leading treatment for multiple sclerosis. Used already by more than 55,000 patients in the United States, Europe and Canada, approvals are now on the horizon in Australia, central and eastern Europe, Turkey and South Africa.

Multiple sclerosis can be a fatal disease in which the body's immune system attacks the wrap-around myelin sheath that surrounds nerve fibers -- sort of like stripping the plastic insulation that covers electrical wire. One of the worst things about multiple sclerosis is that its victims live in constant fear that their bodies will short-circuit and drift into total helplessness. But Avonex, a form of interferon beta that regulates the body's immune response, is proven to slow the attack.

When the company brought Avonex to market in 1996, it became the first fully owned proprietary product of Biogen's portfolio. And the bottom line shows it: Biogen's 1997 revenues grew nearly 60% as earnings per share vaulted more than 110%. Last year's total revenues grew 35% to $557.6 million with EPS advancing a very respectable 55% to $1.80.

Catching up with the drug stocks
Two analysts, Richard van den Broek of Hambrecht & Quist and Albert Rauch of Everen Securities, say the difference in valuation between the stocks of major pharmaceuticals and biotech companies is quite large at the moment. The reason, they say, is because large drug stocks have done so well over the past year. To compare, Rauch uses the PEG ratio (P/E to growth rate), which for drug stocks is currently 2.4 and for "profitable biotechnology companies" is 1.6. Says Rauch, "I see the large-cap biotech stocks increasing their valuations just to catch up with the drug stocks."

Van den Broek expects this year's earnings per share at Biogen to grow 40% to $2.51 with earnings per share increasing another 17% to $2.93 in 2000. Just a bit more upbeat, Rauch expects EPS to hit $2.62 this year followed by $3.04 for 2000 with a long-term target price of $119.

To help meet those goals, the company got terrific news on March 1: The U.S. Food and Drug Administration rebuffed a competing drug, Rebif, from Serono Laboratories. Analysts now expect Biogen to maintain its U.S. Avonex exclusivity through May 2003 under the Orphan Drug Act, which gives incentives for drugs used in treating rare afflictions.

Rauch expects Avonex's 1999 sales to grow more than 42% to $562 million, which is greater than the entire company's revenues during 1998. Though Avonex is outselling its next direct competitor 2 to1 and is by itself 60% of the multiple sclerosis drug market, Rauch estimates that only a third of multiple sclerosis patients are now being treated. He believes Avonex will grow to have annual sales of $845 million by 2003.

When it was a young biotech firm, Biogen -- as small biotech companies do today -- licensed out its discoveries to the big drug companies. Rauch is counting on 1999 royalties of $174 million from partnership products including:

--Cancer-viral drug Intron A, an alpha interferon targeted at 16 different therapies, developed with partner Schering-Plough (SGP).

--Hepatitis B vaccines developed with SmithKline Beecham (SBH) and Merck.

--Hepatitis B diagnostics developed with Abbott Laboratories (ABT) and others.

Coleman Lannum, biotech and medical devices analyst at Putnam Investments, says he believes Biogen has some "potential blockbusters" in its pipeline worth "conservatively" hundreds of millions of dollars, but those products are at least a couple of years away from commercialization. Once a product passes through phase 1, 2 and 3 trials, it can then file an application with the FDA, which will approve or reject a drug for use by patients in the U.S.

This is what the pipeline looks like today:

Avonex, already on the market for relapsing forms of multiple sclerosis, is in phase 3 studies for other forms of the disease, as well as phase 2 trials for brain tumors and pulmonary fibrosis, which makes breathing difficult. On Feb. 18, Biogen announced that it would pay Inhale Therapeutic Systems (INHL) $25 million to begin development of an inhaled formulation for Avonex.

Antova, a monoclonal antibody, is in phase 2 clinical testing for idiopathic thrombocytopenic purpura, a platelet disorder characterized by spontaneous bleeding into the skin.

Antova is also in phase 2 clinical studies for systemic lupus erythematosus, an inflammatory connective tissue disease affecting everything from joints to kidneys. Rauch estimates Antova's potential to be around $1.5 billion.

Amevive, a protein that inhibits T-cell function, is in phase 2 trials for psoriasis. It is expected to come to market in the first half of 2002 with a market potential of $3.6 billion, according to Rauch.

Adentri is in phase 2 trials to relieve water retention of congestive heart failure.

Gelsolin is in phase 2 collaboration with Merck. Gelsolin intends to treat inherited disease cystic fibrosis, a lung disorder that is ultimately fatal.

Rauch says there's a lot of energy in large biotech stocks right now -- and that goes double for Biogen, due to its strong Avonex sales. Van den Broek calls Biogen a "growth story with great momentum." If they're right, this is one biotech that could challenge the industry's leaders.

moneycentral.msn.com