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Biotech / Medical : Monsanto Co. -- Ignore unavailable to you. Want to Upgrade?


To: Dan Spillane who wrote (1493)3/5/1999 8:20:00 AM
From: John F Beule  Respond to of 2539
 
CORRECTED-DuPont/Monsanto could dominate farming for decades

In LONDON story headlined Du Pont/Monsanto could dominate farming for decades, please read in paragraphs seven and eight....

On Tuesday, Britain' biggest player in the field, Zeneca, estimated the global agrobiotech industry could be worth around $75 billion by 2020 compared with just $33 billion today.

But this is modest compared with Du Pont's estimates of $500 billion a year by 2020, followed by Monsanto's forecast of $100 billion by 2015....instead of...

On Tuesday, Britain' biggest player in the field, Zeneca, estimated the global industry could be worth around $700 billion by 2020 compared with just $33 billion today.

While Zeneca posits a relatively modest share of $75 billion for itself, the company's own figures estimate the agricultural biotech market will be dominated by Du Pont with sales of $500 billion a year by 2020, followed by Monsanto on $100 billion.... (Correcting interpretation of forecasts).

A corrected story follows.

By Jonathan Birt

LONDON, March 3 (Reuters) - A merger between Du Pont Co <DD.N> and Monsanto Co <MTC.N> could create a company capable of dominating the world's fast-changing farming industry for decades to come.

Combining the two businesses -- a project still firmly on the drawing board according to reports in the New York Times -- would immediately create the biggest seller of products for agriculture, with annual sales of more than $6 billion.

It would surge past Europe's Aventis, currently being formed from the merger of Germany's Hoechst AG <HOEG.F> with France's Rhone-Poulenc SA <RHON.PA>, on $4.5 billion, and leave Switzerland's Novartis AG <NOVZn.S> and Britain's Zeneca Group Plc <ZEN.L> trailing.

Despite its scale, analysts believe a merger would probably slide past antitrust authorities based on the group's existing portfolios, which are largely complementary. But they argue the real significance of the deal could lay a decade or more away, when the anticipated biotechnology revolution in world farming takes off.

At stake is the creation of an industry that could dwarf the current agrochemicals business, which has grown up since 1945 around chemical treatment of insects and diseases through pesticides and herbicides, plus provision of fertilizers and nutrients to encourage growth.

But the unravelling of the genetic make up of plants, in tandem with that of humans, promises to revolutionise the way crops are raised, creating superbreeds of plants capable of fighting off diseases and insects.

On Tuesday, Britain' biggest player in the field, Zeneca, estimated the global agrobiotech industry could be worth around $75 billion by 2020 compared with just $33 billion today.

But this is modest compared with Du Pont's estimates of $500 billion a year by 2020, followed by Monsanto's forecast of $100 billion by 2015.

The prize for the two U.S. groups and their main European rivals, which also include the Germans BASF AG <BASF.F> and Bayer AG <BAYG.F>, is using genetic understanding of plants to create in-built resistance to disease, insects and chemicals used to destroy unwanted vegetation. Eventually farmers will use genetically-altered crops to boost yield and improve plant quality -- the area with the largest sales potential.

"It is a period of tremendous excitement. I have seen more change in this industry in the last two or three years than since its inception in the post-war years," Zeneca Agrochemicals research and development director Dr David Evans told a meeting of analysts on Tuesday.

Monsanto has led the way in the coming revolution, creating a brand of soya which is resistant to its own herbicide Roundup, and working on corn which is genetically-engineered to resist insects and tolerate herbicides.

Companies on both sides of the Atlantic have started to pour ever greater sums into biotech research. Monsanto spent $4 billion buying three seeds genomics companies in 1997, while Du Pont shelled out $1.7 billion buying a 20 percent stake in another major seed company, Pioneer Hi-Bred International. "You have to position now in order to get research and development in on the new genes, to get them into seeds and on to the market," HSBC agropharma analyst Brian Wilkinson said.

"That is an eight to ten year process. To be ready for this market when it takes off in 2010/2015 you have got to make these investments now."

Novartis, which some believe has been in danger of slipping behind in the biotech race, last year announced it was spending $600 million to build an agricultural research center in San Diego, and Zeneca said this week its biotech spending would treble this year to $60 million from $20 million in 1997.

"Thanks to the formation of Aventis, the European position in agrobiotech is very sound. Novartis is still a player to be reckoned with," Wilkinson said, adding that Zeneca was also positioning itself "astutely" in the fledgling sector.

However, putting together Du Pont's financial muscle with the technology base Monsanto has spent several years and billions of dollars creating will raise the stakes for European players who have led the industry to date.

"There is an industrial logic to this," Paribas analyst Philip Morrish said. "Du Pont has a lot of money and it would take them further in the direction they want to go.

But HSBC's Wilkinson added: "This would be a very significant challenge to life science companies in Europe."

06:20 03-05-99

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To: Dan Spillane who wrote (1493)3/5/1999 8:58:00 AM
From: Thai Chung  Read Replies (1) | Respond to of 2539
 
March 5, 1999

Monsanto Arthritis-Pain Drug
Surpasses Viagra's Sales Success

By THOMAS M. BURTON
Staff Reporter of THE WALL STREET JOURNAL

Monsanto Co.'s new arthritis-pain drug, Celebrex, has surpassed
impotence medication Viagra in generating record numbers of
daily prescriptions early in its marketing cycle.

Celebrex, now in its seventh week on the market, is on track to
becoming the top-selling drug ever as measured in generating
early sales. Market researchers NDC Health Information Services
found that in three of the last four days, Celebrex surpassed the
total prescriptions generated by Pfizer Inc.'s Viagra at a
comparable stage in its marketing cycle.

"It could become a $2 billion drug this year," said Shel Silverberg,
senior vice president of NDC, which supplies marketing
information to the pharmaceutical industry. "This drug seems to
be causing the market to expand." That is a phenomenon that
occurred with some other successful recent drugs, such as Eli Lilly
& Co.'s antidepressant Prozac and its antipsychotic drug Zyprexa.
In the pain market, ibuprofen still leads with more than 30% of
total prescriptions, in addition to over-the-counter sales.

Merck Faces Hurdle

Having already seized more than 20% of the arthritis-pain market,
Celebrex also is well on its way to posing a high hurdle for Merck
& Co., which will be selling a competing drug, Vioxx, as early as
next month on the U.S. market. Doctors and industry officials
estimate that roughly one-third of arthritis sufferers are considered
"dissatisfied" with their current medication, and eager to embrace a
new one.

But, since Celebrex likely will be used by most of those patients by
the time Vioxx will be considered for Food and Drug
Administration approval in late April, Merck may have to consider
whether to try to undercut Celebrex in price. (Merck officials said
that hasn't been decided.) Since the average dose of Celebrex runs
close to $3 a day at many drugstores, Merck may need to consider
whether to focus on another third of the arthritis market. Those
are the patients, many of them elderly, who don't have insurance
coverage for the prescription and find it hard to afford Celebrex.

Celebrex and Vioxx are the forerunners of a new class of pain
drugs known as Cox-2 inhibitors because they act against an
enzyme called cyclooxygenase-2. The drugs are believed to avoid
some of the gastrointestinal side effects that occur in some patients
who use older medicines.

Paradoxically, Celebrex is a rocket ship that hasn't lately boosted
the stock price of Monsanto. Many investors are concerned about
other Monsanto enterprises, such as the heavy debt load it took on
to buy $8 billion in seed companies and other investments in
speculative agriculture biotechnology ventures. Investors, too, are
concerned about the future form of Monsanto because it is
engaged in talks regarding possible business combinations with
DuPont Co. and other companies.

Drug Helped Share Price

While Celebrex's spectacular start did help propel Monsanto from
$37.25 a share on Jan. 19, when the drug was launched, to as high
as $50 a share in early February, the share price settled at $44
earlier this week before news of possible takeover talks emerged.
Monsanto shares closed at $46.1875 in New York Stock
Exchange composite trading Thursday, down 43.75 cents.

Pfizer is co-marketing Celebrex with Monsanto's Searle drug
division, and also is the maker of Viagra, whose sales started
slipping in its sixth week on the market.

Celebrex generated 51,808 prescriptions on Monday compared
with Viagra's 51,728 on the Monday of its seventh week on the
market. Viagra was at 58,893 on Monday of its sixth week,
significantly exceeding Celebrex's 38,789 on Monday a week ago.

Pfizer and Monsanto haven't specified how Celebrex profits are
split, but some Wall Street analysts have estimated that Monsanto
will keep 55% to 60%.

The pain market is fast becoming more complex, with the
emergence of Abbott Laboratories as a co-marketer of Boehringer
Ingelheim's new pain drug Mobic in the U.S. But Abbott will face
the same obstacle that Merck will: If the so-called dissatisfied
patients conclude that Celebrex works for them, they are unlikely
to switch drugs anytime soon. Doctors say that a new arthritis
drug often will work for at least a year in new patients before they
find they need to try a new medicine for their pain.