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Biotech / Medical : Cistron Biotechnology(CIST)$.30 -- Ignore unavailable to you. Want to Upgrade?

To: Walter Morton who wrote (1999)	3/7/1999 1:46:00 AM
From: Walter Morton	Read Replies (1) \| Respond to of 2742

Following primary HIV infection, a state of chronic, persistent infection usually ensues, fueled by cellular activation. The expression of virus over time is determined by a number of viral as well as host factors. Paramount among host factors are endogenous cytokines that tightly control HIV expression in an autocrine and paracrine manner. For example, TNF-a, IL-1b, and IL-6, which are overexpressed in lymphoid tissue of HIV-infected individuals, potently induce HIV replication, and virus replication can be markedly downregulated by blocking these autocrine pathways. A number of factors--including the b-chemokines RANTES, MIP-1a, and MIP-1b--directly downmodulate virus expression in certain culture systems. Suppression of HIV replication by the b-chemokines depends on the culture system employed as well as the cellular tropism of the virus. In certain culture systems, CD8+ T-cell factors other than the b-chemokines are responsible for suppressing HIV replication. The net expression of virus is determined at least in part by the balance of these opposing factors.