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Biotech / Medical : VVUS: VIVUS INC. (NASDAQ) -- Ignore unavailable to you. Want to Upgrade?

To: Mkilloran who wrote (19722)	3/13/1999 8:49:00 PM
From: DaiS	Respond to of 23519

MK, I had not thought seriously about ED gene therapy for women! My first reaction is that while I can envisage 6 monthly gene therapy injections for men, I cannot somehow visualise women going in for injections in their clitorises (or whatever the plural). Don't you think they would prefer a cream! Women don't HAVE to get it up to a certain hardness - or do they - and I'm sure have more important things in life to worry about. Am I being sexist? I would like to see the Berman/Goldstein viagra study abstract - BigK posted part, "Using this methodology, sildenafil appears to enhance the female sexual response to visual and vibratory stimulation. Pre-and post stimulation vaginal pH levels were significantly increased with sildenafil compared to placebo. Genital blood flow, primarily clitoral, increased as well. In this population of women, vasoactive agents such as sildenafil may improve sexual complaints associated with diminished genital blood flow." to see how it can be reconciled with the results of Kaplan published in Urology which showed dismal results for viagra. I suspect it might relate to the method of measuring response, I recall that Goldstein used vibrators in that topiglan study. When viagra was launched here we had a flurry of ED programmes on TV. One showed a trial being conducted with a woman. She took viagra and was encouraged to stimulate herself in a relaxing enviroment. There was no talk of placebo in that instance but anyway the woman did not benefit. This is just one woman, but I mention because the programme then suggested an important difference between men and women! A man on viagra can see before his eyes the effect of the drug as he becomes excited. This has a positive feedback effect. With a woman there is not much to see so the effect of the drug is more ambiguous. Since the alprostadil cream can be expected to produce engorgement of a woman's genitalia, and maybe some warmth perhaps this will be more useful. As women are familiar with using lubricants and creams, there is nothing to make fun of either as compared with muse. The patent refers to SEPA and DMSO and mentions that the former is available from Machrochem. This surprised me, are Macrochem selling the stuff! One thing we do not know is whether the Vivus cream will have to have an uptake enhancer. I think that some reports referred to other companies testing alprostadil creams. Does anyone know anything about this? If this is true how could Vivus get a patent? DaiS