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Pastimes : Don't Ask Rambi -- Ignore unavailable to you. Want to Upgrade?

To: Gauguin who wrote (19362)	3/15/1999 2:36:00 PM
From: Ilaine	Read Replies (1) \| Respond to of 71178

Wow, that was weird. I was typing a response, opened my Goodman & Gilmans to the correct page, I had the response screen already there, and when I looked at the partially typed response, it was gone. NSAIDs and opiates work in different ways. NSAIDS inhibit cyclooxygenase, "the enzyme responsible for the biosynthesis of the prostaglandins and certain related autocoids." This stuff ain't easy, you know. Celebrex is the Queen of NSAIDs, it only inhibits cyclooxygenase ("COX")-2, not COX-1, which protects the stomach lining. Opiates fit on receptors in the brain, and the central nervous system. Mechanism something like keeping Substance P (the pain giver) from being able to fit into the receptors, or maybe mimicking endorphins. People who are drowning or being eaten by lions or freezing to death, if they are rescued, tell of a good warm feeling that comes over them. That's endorphins, the body's own opiate. If you work out and get high, the so-called "runner's high", that's endorphins, too. Opiates are good with so-called nociceptive pain, that is, pain stimulated over intact neural structures. A lot of drugs given for post-surgical pain include both NSAIDs and opiates. I strongly suggest that you try Celebrex.