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Biotech / Medical : XOMA. Bull or Bear? -- Ignore unavailable to you. Want to Upgrade?

To: aknahow who wrote (9299)	3/20/1999 7:08:00 PM
From: Tharos	Respond to of 17367

Some info on emerging diseases: From Emerging Infectious Diseases Mycoplasma penetrans Bacteremia and Primary Antiphospholipid Syndrome1 [Emerging Infectious Diseases 5(1), 1999. Centers for Disease Control] -------------------------------------------------------------------------------- Introduction Mycoplasma penetrans, a rare bacterium so far only found in HIV-infected persons, was isolated in the blood and throat of a non-HIV-infected patient with primary antiphospholipid syndrome (whose etiology and pathogenesis are unknown). Antiphospholipid syndrome (APS), first described in 1983 to 1986, is characterized by a wide variety of hemocytopenic and vaso-occlusive manifestations and is associated with antibodies directed against negatively charged phospholipids. Features of APS include hemolytic anemia, thrombocytopenia, venous and arterial occlusions, livedo reticularis, pulmonary manifestations, recurrent fetal loss, neurologic manifestations (stroke, transverse myelitis, Guillain-Barrè syndrome); and a positive Coombs test, anticardiolipin antibodies, or lupus anticoagulant activity[1]. The factor(s) causing production of the antiphospholipid antibodies in primary antiphospholipid syndrome (PAPS) remain unidentified[2]. A substantial number of patients with Mycoplasma pneumoniae–induced respiratory disease[3]. Furthermore, many clinical criteria for APS have also been well documented in patients with M. pneumoniae infection, including Guillain-Barrè–like illness and other central nervous system manifestations, hemolytic anemia, positive Coombs test, thrombocytopenia, and arthritis[4]. In this report, we describe the case of a patient with clinical features of PAPS and a documented bacteremic infection due to M. penetrans[5]. more at: http://id.medscape.com/3254.rhtml