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Biotech / Medical : PFE (Pfizer) How high will it go? -- Ignore unavailable to you. Want to Upgrade?


To: BigKNY3 who wrote (7272)3/22/1999 8:32:00 PM
From: Anthony Wong  Read Replies (1) | Respond to of 9523
 
03/22 19:46 Merck <MRK.N> launching pain drug Vioxx in Mexico

MEXICO CITY, March 22 (Reuters) - U.S. pharmaceutical giant Merck and
Co. Inc. said on Monday that Mexico would be the first market where its
new pain reliever Vioxx would be available with its launch here this week.

"Mexico will be the first country in the world to have Vioxx available," a
statement from the company's Merck Sharp and Dohme unit said. It said
Mexican health authorities approved the drug on Feb. 1.

Vioxx is one of a new line of pain relievers known as Cox-2 inhibitors
designed to treat pain and arthritis without the gastrointestinal side effects
often seen in aspirin and ibuprofen.

Brisk initial U.S. sales of G.D. Searle & Co's <MTC.N> Cox-2 inhibitor,
Celebrex, have put it on track to top Pfizer Inc. <PFE.N> impotency drug
Viagra as the most successful drug launch ever.

Vioxx is due to be reviewed by a U.S. Food and Drug Administration
advisory committee in April, with approval expected this spring.
Germany's Boehringer Ingelheim also has a Cox-2 drug expected to be
approved in the U.S. late this year.

moneynet.com@NEWS-P1&Index=0&HeadlineURL=../News/NewsHeadlines.asp&DISABLE_FORM=&NAVSVC=News\Company



To: BigKNY3 who wrote (7272)3/23/1999 9:53:00 AM
From: Anthony Wong  Read Replies (1) | Respond to of 9523
 
Aventis to Be World's No. 1 Drugmaker, IMS Indicates (Update2)

Bloomberg News
March 23, 1999, 9:12 a.m. ET

Aventis to Be World's No. 1 Drugmaker, IMS Indicates (Update2)

(Adds drugmakers' shares in 6th paragraph.)

London, March 23 (Bloomberg) -- Aventis SA, the product of
Hoechst AG's planned union with Rhone-Poulenc SA, will be the
world's No. 1 drugmaker, ahead of the company to be formed by
Zeneca Group Plc's purchase of Astra AB, according to IMS Health
Inc., which tracked 1998 drug prescriptions.

The IMS rankings move Aventis, AstraZeneca and Novartis AG
-- which was formed by a 1996 merger between Swiss drugmakers --
ahead of Merck & Co. of the U.S., which ranked No. 1 in 1997.
IMS estimated worldwide prescription drug sales grew about 3
percent to $302 billion last year.

European drugmakers' dominance may be short-lived, though,
because they've grown by combining with one another rather than
by selling more drugs, analysts said. In three separate
agreements in December, six European companies said they'd join
forces as they sought to spread the costs of research and
marketing and boost drug development to take on U.S. rivals.

''U.S. drugmakers are enjoying the introduction of new
products,'' said Jo Walton, an analyst at Lehman Brothers in
London. By contrast, ''European companies are coming together to
get an earnings bridge until they have more new products to
support sales.''

Agreements in December between Hoechst of Germany and Rhone-
Poulenc of France, which had combined prescription drug sales of
$10.795 billion last year according to IMS, and Astra and
Zeneca, with revenues of $10.681 billion, capped a year which
saw New York-based rival Pfizer Inc. pull off the most
successful drug introduction yet with its impotence pill Viagra.

Shares Decline

Drugmakers' shares fell today as investors took recent
mergers as evidence companies are joining forces to cushion the
effect of slower growth. Hoechst shares fell 1.45 euros, or 3.5
percent, to 40.15 euros ($43.60). Glaxo Wellcome Plc declined 30
pence, or 1.6 percent, to 1,871p ($30.40). The Bloomberg index
of 24 European pharmaceutical stocks fell 1.2 to 181.37.

Novartis -- the product of the 1996 merger of Sandoz AG and
Ciba-Geigy AG -- had prescription drug sales of $10.639 billion
last year, according to IMS, which tracked sales through
wholesalers and retailers. Merck's sales totaled $10.635 billion
last year, IMS said.

Excluding the impact of the recently announced mergers,
Novartis rose to the No. 1 slot from No. 3 in 1997, less than a
week after it warned profit growth this year will slow. Still,
among the company's new drugs, products including a treatment
for asthma and one for a bowel disorder are expected to reach
the market in the next couple of years, boosting future sales,
analysts said.

Other drugmakers are following in Novartis's footsteps,
hoping to keep earnings growing by cutting costs and funneling
money into research that they hope will yield the next Viagra.

Rash of Mergers

Last week Hoechst and Rhone-Poulenc said they will speed up
their planned merger, while U.K.-based Zeneca said it expects to
win U.S. regulators' approval soon to buy Sweden's Astra for $35
billion. Meanwhile, Germany's Bayer AG announced plans to make
acquisitions in the face of falling chemical prices, and
France's Sanofi SA won European regulators' approval to buy
Synthelabo SA.

IMS rankings can differ from drugmakers' own estimates of
their size because they're based on prescription drug sales
alone. That means drugs such as the over-the-counter (non-
prescription) form of Glaxo Wellcome Plc's Zantac aren't
included in IMS's sales tally. Companies usually don't publish
separate figures showing their prescription-drug sales alone.

IMS published sales estimates only for companies in
existence in 1998. AstraZeneca's and Aventis's sales were
computed by Bloomberg News based on the merger candidates' 1998
sales totals.

Hoechst, for example, had sales of $6.225 billion last year
and moved down to No. 13 from No. 9 in the latest IMS rankings.
Rhone-Poulenc, with sales of $4.570 billion, kept its No. 17
place, IMS said.

Rhone-Poulenc's board meets today at 3:00 p.m. French time
to vote on the merger of the companies' drug and crop-protection
businesses. Most of Rhone-Poulenc's 15 board members will
probably approve the plan, as they did on Nov. 30, analysts
said. Only union officials, who have three seats on the board,
have said they're likely to oppose the merger.

'Too Close to Call'

Excluding the impending mergers, IMS's rankings show
Novartis and Merck ranked first and second, respectively. Glaxo
Wellcome of the U.K., born from Glaxo Plc's 1995 purchase of
Wellcome Plc, is No. 3 and Pfizer is No. 4, having risen from
No. 6 last year.

''We believe the top three pharmaceutical companies are in
a three-way tie for first place,'' IMS Health Chief Executive
Victoria Fash said in a statement. ''Novartis, Merck and Glaxo
Wellcome are separated by just millions of dollars, and it is,
in our view, a race that is too close to call.''

Rounding out the top 10 IMS-ranked drugmakers, in order,
were New Brunswick, New Jersey-based Johnson & Johnson; Madison,
New Jersey-based American Home Products Corp.; Basel,
Switzerland-based Roche Holding AG; Indianapolis-based Eli Lilly
& Co., and U.K.-based SmithKline Beecham Plc.



To: BigKNY3 who wrote (7272)3/23/1999 10:00:00 AM
From: Anthony Wong  Read Replies (1) | Respond to of 9523
 
Viagra becomes available in Japan

March 23, 1999
Web posted at: 3:11 AM EST (0811 GMT)

TOKYO, March 23 (Reuters) - The anti-impotence drug Viagra became
available in Japan on Tuesday after receiving approval in a matter of months.
Officials at Pfizer Pharmaceuticals Inc, a division of U.S.-based Pfizer Inc,
said they had high expectations for the much-heralded drug, which went on
sale in the United States nearly a year ago.

"Japan is the world's second-largest market for pharmaceuticals, so of
course we look forward to strong sales in line with this," said Takaichi
Hirota, manager of product communications at Pfizer Pharmaceuticals.

He declined, however, to give specific sales projections.

"Erectile dysfunction is a serious condition and those who suffer from it tend
to suffer alone and in silence," Hirota added. "But now there is help for these
people, and this is a very good thing."

The number of Japanese men suffering from impotence is estimated at six to
seven million, media reports say.

Viagra will be available only with a doctor's prescription and will not be
covered by health insurance, but Pfizer's Hirota said he could not tell if this
would dampen sales.

A 25-milligram tablet will cost 1,100 yen ($9.32) and a 50-milligram tablet
1,300 yen, roughly in line with prices in the United States.

Men must also foot the bill for pre-prescription tests, estimated at 10,000
yen or more. These include urine and blood tests and an electrocardiogram.

Birth control activists have been up in arms about Viagra's unusually rapid
approval on January 25 after only six months of deliberations and despite
more than 130 deaths worldwide attributed to its use since it went on sale
last year.

In contrast, the birth control pill has yet to be made widely available in Japan
nearly three decades after it appeared in the West.

Opponents of the pill have raised concerns that it would promote
promiscuity, lead to a rise in sexually transmitted diseases and even cause
reproductive troubles if estrogen-tainted waste from users made its way into
the environment.

While Japan's Health Ministry appears likely to finally grant approval to a
low-dose pill in June this year, any prescription will carry with it a long list of
caveats and rules, including requiring periodic tests for sexually transmitted
diseases.

Viagra faces none of these regulations, prompting advocates of the pill's
approval to cry foul.

"Men's well-being is very important in Japan, but not women's," said Midori
Ashida, secretary of the Professional Women's Coalition for Sexuality and
Health.

"For women, the most important thing in this society is to have children, and
the pill is a drug to avoid having children."

Pfizer's Hirota said his company was pleased with the rapid approval given
Viagra.

"The problems of Viagra and the pill are completely different, and linking
them is a bit strange," he said.

Production of the drug started at a factory in central Japan immediately
following its approval in January and has been proceeding at a high pitch
ever since, under extremely tight security to prevent theft, Japanese media
reports say.

Copyright 1999 Reuters. All rights reserved. This material may not be published, broadcast,
rewritten, or redistributed.

cnn.com