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Biotech / Medical : Biotransplant(BTRN) -- Ignore unavailable to you. Want to Upgrade?

To: LLCF who wrote (243)	4/8/1999 4:24:00 PM
From: scaram(o)uche	Read Replies (1) \| Respond to of 1475

Again, while this is the program that Novartis supports and while I feel that it would be wise for them to continue to do such, this is the portion of the work at MGH/BTRN that I am least enthusiastic about (great work, but barriers to commercialization)....... J Immunol 1999 Mar 15;162(6):3402-7 Normal development in porcine thymus grafts and specific tolerance of human T cells to porcine donor MHC. Nikolic B, Gardner JP, Scadden DT, Arn JS, Sachs DH, Sykes M Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, Boston 02129, USA. [Medline record in process] The induction of T cell tolerance is likely to play an essential role in successful xenotransplantation in humans. In this study, we show that porcine thymus grafts in immunodeficient mice support normal development of polyclonal, functional human T cells. These T cells were specifically tolerant to MHC Ags of the porcine thymus donor and responded to nondonor porcine xenoantigens and alloantigens. Exogenous IL-2 did not abolish tolerance, suggesting central clonal deletion rather than anergy as the likely tolerance mechanism. Our study suggests that the thymic transplantation approach to achieving tolerance with restoration of immunocompetence may be applicable to xenotransplantation of pig tissues to humans. Transplant Proc 1999 Feb;31(2B):957 Xenogeneic thymic transplantation in a pig-to-nonhuman primate model. Wu A, Esnaola NF, Yamada K, Awwad M, Shimizu A, Huang C, Wain J, Zhao Y, Neville DM Jr, Cooper DK, Sykes M, Sachs DH Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, USA. [Medline record in process] Transplant Proc 1999 Feb;31(2B):924 Porcine thymus supports development of human T cells that are tolerant to porcine xenoantigens. Nikolic B, Sykes M Bone Marrow Transplantation Section, Massachusetts General Hospital/Harvard Medical School, Boston 02129, USA. [Medline record in process]