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To: scaram(o)uche who wrote (811)4/20/1999 1:01:00 PM
From: Jim Oravetz  Respond to of 1073
 
TUMOR OXYGEN LEVEL AND BLOOD FLOW FLUCTUATE, DUKE SCIENTISTS DISCOVER

PHILADELPHIA - In a discovery that might help explain why widely used cancer therapies are less than optimal, Duke University Medical Center researchers have found that a tumor's oxygen level and blood flow can fluctuate rapidly.

The Duke animal study, which contradicts previous assumptions about tumors, could be important because the two major cancer treatments, radiation and chemotherapy, depend on a constant high oxygen level and steady blood flow within a tumor, scientists said.
"These fluctuations in oxygen level and blood flow are not predictable and might represent an impediment to radiation therapy and drug therapy," said Mark Dewhirst, co-director of the radiation oncology and hyperthermia program at Duke Comprehensive Cancer Center and associate professor of pathology. "Before this work, there was no way to reliably measure these values."

Dewhirst prepared the findings for presentation Tuesday at an American Association for Cancer Research meeting. His study, which was done in collaboration with Rod Braun, assistant professor in radiation oncology, was funded by the National Cancer Institute. A report based on the results of this study has been accepted for publication by the American Journal of Physiology....snip...

dukenews.duke.edu

Jim