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Biotech / Medical : VVUS: VIVUS INC. (NASDAQ) -- Ignore unavailable to you. Want to Upgrade?

To: VLAD who wrote (20873)	4/20/1999 5:03:00 PM
From: DaiS	Read Replies (1) \| Respond to of 23519

Vlad, <The good thing to know is that PDE-5 inhibitors CAN be absorbed transurethrally and they DO work via the local delivery method. This is great news for us since Vivis holds the transurethral delivery patents.> I agree with you 100%. You might recall that Doherty (and others) also had an abstract at the Amsterdam conference last year, injecting different PDE inhibitors into cats. But that was injection not transurethral delivery. So it seems to me that the current AUA abstract is the first scientific evidence we have that PDE-5 inhibitors can be absorbed transurethrally and be effective....something we have speculated about repeatedly over the last year. It also indicates that the claims of the Indonesian (I think) company were not without foundation. The AUA study of the muse/viagra combo also augurs well for transurethral mixes involving PDE inhibitors. I assume that local delivery of a PDE inhibitor would require quite small doses, thus any systemic effects would be small, unlike with viagra? Why did Vivus go for PGE/alprostadil at the start? ....Leland emphasised recently it is a natural substance (very high concentration in semen eg)?...it is an erection producer, targeting more severe ED?...it is absorbed transurethrally very well (no need for SEPA)?...it is broken down very quickly in the body (unlike viagra/metabolites)?...no suitable PDE inhibitors 4-5 years ago???? From my own DD and after reading the Vivus patents I suspect that Vivus et al. have had all this covered for years. Put it another way, if trimixes etc have a future you can be damn sure that Vivus have been onto it for a very long time. Remember what Leland said last year about viagra "..they have a great drug there but it should be delivered transurethrally...". Let's see if your speculations about the new drug Vivus has acquired turn out to be right!!! DaiS I don't forget my task re Astra/Zeneca