Silicon Investor (SI) -- The First Internet Community

STOCKTALK

We've detected that you're using an ad content blocking browser plug-in or feature. Ads provide a critical source of revenue to the continued operation of Silicon Investor. We ask that you disable ad blocking while on Silicon Investor in the best interests of our community. If you are not using an ad blocker but are still receiving this message, make sure your browser's tracking protection is set to the 'standard' level.

Biotech / Medical : Neurobiological Tech (NTII) -- Ignore unavailable to you. Want to Upgrade?

To: Apache Indian who wrote (531)	4/30/1999 5:57:00 PM
From: Dr. John M. de Castro	Read Replies (1) \| Respond to of 1494

Apache Indian, it happens very often when a stock pops like NTII did. The buy orders come in fast and furious and often overwhelm the inventory of shares that the MMs have. So, they raise the price and sell shares short. After the furor has died down, the MMs slowly bring the stock value down and then purchase the shares to cover their shorts at a much lower price than they sold them for. A dead giveaway that this is occurring is that the MMs discourage buying. they do so until they've collected enough shares to cover their short positions. They discourage buying by increasing the ask to rediculous levels and refuse to fill any orders between the bid and ask. This is exactly what has happened to NTII the last two days. Have a great weekend John de C

To: Apache Indian who wrote (531)	5/17/1999 2:06:00 PM
From: Dr. John M. de Castro	Read Replies (1) \| Respond to of 1494

Xerecept (aka CRF) is effective against trauma induced edema. NTII is evaluating Xerecept for peritumoral edema. This study suggests that it may be useful for a broader range of indications where cerebral edema is a problem. John de C Acta Neurochir Suppl (Wien) 1998;71:149-52 The effect of human corticotrophin releasing factor on the formation of post-traumatic cerebral edema. Beaumont A, Marmarou A Division of Neurosurgery, Medical College of Virginia, Virginia Commonwealth University, Richmond, USA. Controlled cortical impact is a well validated model of cortical contusion which is known to produce cerebral edema. Corticotrophin Releasing Factor (CRF) is a hypothalamic neuropeptide, which is known to inhibit transendothelial leakage of plasma derived fluid and tissue edema in response to injury. The aim of this study was to determine cerebral edema after controlled cortical impact and then compare the effect of high and low doses of CRF. We evaluated the effect of CRF in rats divided into groups of sham, trauma alone, and trauma treated with CRF at 50 micrograms/kg and 100 micrograms/kg. Animals were sacrificed at 24 hours and water content was determined. We found that CRF was effective in reducing cerebral edema associated with cortical contusion and propose that the action of CRF obviated barrier leakage.