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Biotech / Medical : VVUS: VIVUS INC. (NASDAQ) -- Ignore unavailable to you. Want to Upgrade?

To: John M. Gelnieau who wrote (21531)	5/2/1999 7:22:00 PM
From: DaiS	Respond to of 23519

ED, PE and incontinence Did you know that signals sent out along the sympathetic nervous system inhibit erections, promote ejaculation and relax the bladder? Anxiety, fear and stress increase these signals...impotence ...premature ejaculation .....loss of bladder control... The signals within the sympathetic nervous system can be inhibited by alpha blockers, drugs which can act locally: - within the penis...thus facilitating erections within the ducts of the reproductive system that contract during orgasm....thus counteracting premature ejaculation *within the bladder....thus combatting incontinence Prazosin the second active ingredient in alibra is an alpha blocker that acts locally in this way and thus will damp down the signals caused for example by anxiety that cause psychogenic ED. Fact: Prazosin taken orally has also been advocated/tested as therapy for premature ejaculation AND incontinence! Since prazosin acts locally at nerve endings within the target tissue, it would be quite logical to test its use as a therapy transurethrally for PE and incontinence. Other alpha blockers could be tested, some of these are specific in their action on the urogenital system. I posted last week a link to a patent for use of alpha blockers to treat PE. Vivus might have anticipated and/or observed positive results with alibra in relation to PE. I think that the PE and incontinence products might involve administration of alpha blockers through the urethra. Well I want to point out that there is at least a scientific rationale for this approach. We see that Edderd and doctors such as Dale Russel (see recent exchange with Amots), regard PE as a problem requiring intervention within the CNS, the brain. There is no doubt that PE can be treated by psychological therapy and tricks, but the local approach, as described above, might be very effective. Remember experts used to say that most ED was all in the mind, yet muse, viagra, alibra, IC, pumps etc are all locally acting.