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Biotech / Medical : PFE (Pfizer) How high will it go? -- Ignore unavailable to you. Want to Upgrade?

To: Brander who wrote (7609)	5/5/1999 9:41:00 PM
From: Mkilloran	Respond to of 9523

Brander...read the other press release "Vomiting is one of the side effects" of Uprima #reply-9316589

To: Brander who wrote (7609)	5/5/1999 9:48:00 PM
From: LaVerne E. Olney	Respond to of 9523

Does apomorphine produce vomiting? This drug has been used for may years, like ipecac syrup, for inducing vomiting after poisoning. Apomorphine is used to produce vomiting in cases of poisoning from substances taken orally. optonline.com Of course the Uprima dose is much smaller than the emetic dose and would need to be titrated to each person's nausea susceptibility. From the 1998 AUA meeting: In the other study, men taking apomorphine also showed significant improvement in their ability to have an erection sufficient enough for intercourse compared to those taking a placebo. Those taking apomorphine at a dosage of 2 mg to 6 mg were successful in achieving an erection in approximately 46% to 60% of the attempts compared to 32% to 34% among placebo users, reported researchers led by Harin Padma-Nathan, M.D., the director of the Male Clinic in Santa Monica, Calif. Those taking apomorphine had no known physical cause of erectile dysfunction, such as diabetes or hypertension. The most common side effect of apomorphine was nausea, which occurred among 2.1% of the patients taking the lowest dose and 39% taking the higher dosage. Apomorphine works by stimulating neurological signals to create an erection, while Vasomax blocks adrenergic receptors. Both reports-which involved men with mild to moderate erectile dysfunction-were presented at the annual meeting of the American Urological Association. "I think Viagra will still be the first choice therapy. But it doesn't work in everyone," commented Drogo Montague, M.D., a urologist from the Cleveland Clinic Foundation. "The response seen in these studies [with Vasomax and apomorphine] is not as strong as Viagra but the response was better than placebo," said Dr. Montague, who chaired the AUA committee that developed treatment guidelines for erectile dysfunction in 1996. These other drugs could prove useful for patients who do not respond to Viagra or for those taking medication that would be contraindicated, he said. "The bottom line is that oral medications will significantly change the way we treat erectile dysfunction," the urologist said. But until the other drugs are approved, it is too early to tell whether they will work better than Viagra, he added. web1.po.com