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Pastimes : Don't Ask Rambi -- Ignore unavailable to you. Want to Upgrade?

To: Ish who wrote (24089)	5/6/1999 9:08:00 AM
From: Ilaine	Read Replies (1) \| Respond to of 71178

Just got back from brief PubMed search, input "periodontal" and "coronary", numerous articles, here are the two most recent (abstracts only, which is the most you get on PubMed). The connection between the two is well-documented. Curr Opin Microbiol 1998 Feb;1(1):88-95 Oral pathogens: from dental plaque to cardiac disease. Meyer DH, Fives-Taylor PM Department of Microbiology and Molecular Genetics Stafford Hall University of Vermont Burlington VT 05405 USA. dmeyer@zoo.uvm.edu [Record supplied by publisher] Oral bacteria exhibit highly specific adherence mechanisms and as a result they colonize and cause disease principally in the oral cavity. Oral pathogens, however, can produce systemic disease and are known causative agents of infective endocarditis. Recent studies have revealed that periodontal disease per se is also a statistically significant risk factor for cardiovascular disease. A link between the two diseases is the secretion and systemic appearance in periodontitis of pro-inflammatory cytokines capable of eliciting effects associated with atherosclerosis and coronary heart disease. ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ J Cardiovasc Risk 1999 Feb;6(1):7-11 Periodontal disease and risk of fatal coronary heart and cerebrovascular diseases. Morrison HI, Ellison LF, Taylor GW Cancer Bureau, Health Canada, Canada. howard_morrison@hc-sc.gc.ca [Medline record in process] BACKGROUND: Recent reports have implicated periodontal disease as a risk factor for coronary heart disease (CHD). METHODS: A retrospective cohort study was conducted using participants in the 1970-1972 Nutrition Canada Survey (NCS). The mortality experience of male and female NCS participants aged 35-84 years without self-reported CHD (n = 10,368) or cerebrovascular disease (CVD) (n = 11,251) was determined through 1993. The relation between dental health and the risk of fatal CHD and CVD was assessed using Poisson regression modeling. RESULTS: In total, 466 CHD and 210 CVD deaths were observed; missing confounder data reduced these numbers to 416 CHD and 182 CVD deaths. Adjusted for age, sex, diabetes status, serum total cholesterol, smoking, hypertensive status, and province, we found a statistically significant association between periodontal disease and risk of fatal CHD. Rate ratios (RR) of 2.15 [95% confidence interval (CI) 1.25-3.72) and 1.90 (95% CI 1.17-3.10) were observed for severe gingivitis and edentulous status, respectively. Non-statistically significantly increased RRs of 1.81 and 1.63 were observed for severe gingivitis and edentulous status for CVD. CONCLUSIONS: These data indicate that poor dental health is associated with an increased risk of fatal CHD.