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Biotech / Medical : XOMA. Bull or Bear? -- Ignore unavailable to you. Want to Upgrade?

To: Bluegreen who wrote (10021)	5/17/1999 12:10:00 AM
From: PrometheusTex	Read Replies (1) \| Respond to of 17367

Bluegreen... are you Biostock? And do you have the full article from Feb 99 to which you refer? How did they measure LPS in circulation? Would the results be the same if LPS remained in circulation but was bound in an inactive form? I can get the article if you do not have it, of course, to answer my own question. ProTex

To: Bluegreen who wrote (10021)	5/17/1999 10:12:00 AM
From: Edward Paule	Read Replies (2) \| Respond to of 17367

>>> Protective effect of bactericidal/permeability-increasing protein (rBPI21) in baboon sepsis is related to its antibacterial, not antiendotoxin, properties. <<< The conclusions from this study have me confused. >>> Bacteremia was significantly reduced in the rBPI21 group at 2 hours after the start of the E. coli infusion, whereas circulating LPS was less affected. <<< I assume the measurement was of non-bound free-floating LPS. If rBPI21 had only antibacterial properties and no antiendotoxin properties, I would have expected a dramatic increase in circulating LPS after the "potent" killing of the bacteria. I would then expect the higher LPS levels to produce a negligible difference in survivability. But these events didn't happen. I would conclude that the baboons survived because rBPI21 prevented the increase of active circulating LPS that should have occurred following the death of so many gram-negative bacteria. am I What here? missing - Ed.