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Biotech / Medical : XOMA. Bull or Bear? -- Ignore unavailable to you. Want to Upgrade?

To: John Patterson who wrote (10047)	5/17/1999 7:52:00 PM
From: Bluegreen	Respond to of 17367

In my opinion that will occur whether Neuprex is given or not especially with a G score of 8 or above. Look, LPB is the BIG deal in sopping up LPS anyway NOT Neuprex in my opinion. It is the stimulation of CD14 by LBP that gives you the scenario you describe. Going further, how do you know LPS is the ONLY agent that causes rise in LBP? Still further if Neuprex is so hot in sopping up LPS, why did Xoma get patents on tweaked LBP that DOESN'T kick off CD14? One more time, I agree with the Baboon study. Baboons have LBP also so why do some even talk about free vs bound up LPS?<g> I am not saying Neuprex doesn't have antiendotoxin capabilities, I just happen to think it isn't the main event. Quick question for anyone. Why are antibiotics given for days sometimes weeks in some infections? Wouldn't that suggest not HYPER type war but many battles of regulation and destruction of the bacteria in question? Only my thoughts and opinions I could be totally wrong and I still am confused by some posters.

To: John Patterson who wrote (10047)	5/17/1999 9:44:00 PM
From: Robert K.	Read Replies (1) \| Respond to of 17367

JohnP, you had best read up on Heydermans article again. Anti-phagocytic effect of rbpi protects vascular system from WBC toxins and damage. Also since endotoxin sets off the coagulatory cascade and circulatory block, then blocking endotoxin prevents the cirulatory block.STOP for 1 minute and think about meningo and circulation???????????????????????????????????????????? What happens in meningo to the extremities????????Why ???? And I concur with Cacaito the anti-inflamatory effects DO seem to be fueled by ONGOING endotoxin stimulation(key word is FUELED) probably thru CD14. Has there ever been a product to market that stops the cascade? As yes bluegreen, lbp-dummy. A kick ass concoction in itself. >3 parts with bpi thown in. More potential indications than I care to count.Potential perhaps even exceeding that of bpi21. And I never said perhaps Murphy was being too extreme. Quite the contrary. You know if we ever got a halt in trauma due to efficacy, do you have any idea how the market would react. Doubt it will happen but I wouldnt say it cant. I also kinda doubt we will go 90 days for a meningo result. And should bpi21 prove iteslf as a antibiotic to the media??????Bluegreen knows the answer to that one. Will rbi21 work? I dont know, we just have to wait and see. All IMO, standard disclaimers all apply. Consider nothing as factual.