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Biotech / Medical : Biotransplant(BTRN) -- Ignore unavailable to you. Want to Upgrade?


To: scaram(o)uche who wrote (267)5/25/1999 8:06:00 PM
From: scaram(o)uche  Read Replies (1) | Respond to of 1475
 
Looks like bad news for MEDI/BTRN, but..... is it? I believe that LFA-3 is the only high affinity ligand for CD2 identified to date in humans. LFA-3 has a wide tissue distribution, including non-hematopoietic cells such as endothelial cells, fibroblasts and erythrocytes. Since CD2 is expressed largely if not exclusively on cells of the T lymphocyte lineage and NK cells and all other factors equal (unlikely in biological systems), it is logical to guess ("assume" would be too strong) that it would take less anti-CD2 to block the CD2/LFA-3 interaction than it would take anti-LFA-3.

In addition, there's the holy grail....... the MEDI release mentions it, but provides no further evidence. Looks like BGEN is ripping, and, from what I've seen, MEDI is merely sticking a toe in the water.

It won't be boring! Thanks, PB........
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