SI
SI
discoversearch

We've detected that you're using an ad content blocking browser plug-in or feature. Ads provide a critical source of revenue to the continued operation of Silicon Investor.  We ask that you disable ad blocking while on Silicon Investor in the best interests of our community.  If you are not using an ad blocker but are still receiving this message, make sure your browser's tracking protection is set to the 'standard' level.
Biotech / Medical : PFE (Pfizer) How high will it go? -- Ignore unavailable to you. Want to Upgrade?


To: Dan Spillane who wrote (7757)5/27/1999 11:46:00 PM
From: Little Gorilla  Read Replies (1) | Respond to of 9523
 
Pfizer's Pfocus

by Matt Richey (TMF Verve)

ALEXANDRIA, VA (May 27, 1999) -- Yesterday, we looked at a Warner-Lambert (NYSE: WLA), a company that derives half of its revenue from non-pharmaceutical products such as candy, razors, and a host of other over-the-counter products you might find in your medicine cabinet. While these consumer health care products offer stable cash flow, they dilute Warner-Lambert's overall profit margins and sales growth. In sharp contrast, Pfizer (NYSE: PFE) focuses almost exclusively on high-margin, high-growth pharmaceuticals. This strategy is riskier than the diversified approach of Warner-Lambert, Johnson & Johnson, and Merck, but offers greater rewards, as well.

More than any other big pharma that we look at this week, Pfizer is pharmaceuticals. Over the past eight years, CEO William Steere has sold all non-drug businesses -- even some good ones. Steere called them "distractions." With last year's divestiture of the Medical Technology Group, Pfizer completed its transformation to a 100% pharmaceuticals business.

During the first quarter of this year, the sales breakdown was 93% pharmaceuticals and 7% animal health. Truly, the animal health division is just an extension of the pharmaceuticals business. Animal health maximizes the company's return on investment in human pharmaceutical research so that even when a compound fails in humans, it might find a use in animals. Very Foolish. Even though animal health sales declined year-over-year, it's still a smart investment.

Overall, Pfizer's first quarter results were tremendous. (Here are the links to Pfizer's earnings press release and 10-Q.) I examined the earnings release back in April, but today let's look at the income statement and balance sheet from a Rule Maker perspective.

Looking first at the income statement, the results were quite impressive. Sales surged by 29% on the strength of Norvasc, the world's #1 anti-hypertensive for cardiovascular-related diseases; Zithromax, the most-prescribed brand-name oral antibiotic for a variety of infectious diseases; and Zoloft, a leading anti-depressant. Sales also benefited from strong alliance revenues associated with the co-marketing of Warner-Lambert's cholesterol-lowering Lipitor and G.D. Searle's arthritis-relieving Celebrex. Meanwhile, slower growth in cost of sales caused gross margins to expand to over 86%. Moving to the bottom-line, net income from continuing operations advanced over 52% with net margins moving up to nearly 21%. Some of these profits were used to repurchase shares, leading to a decline in the diluted sharecount. All in all, a terrific quarter of operations.

But we can't jump to any conclusions without seeking confirmation from the balance sheet. Here, the story isn't as impressive. The cash-to-debt and Flow ratios showed good direction, but still fall well short of our standards. Pfizer now has over $4 billion in cash, but some of that is from increases in short-term debt. According to the 10-Q, the additional short-term debt was partly used to fund the repurchase of shares that led to the sharecount decline. Considering that Pfizer's earnings per share (EPS) for the quarter exactly met the consensus analysts estimate, one might worry that Pfizer had to repurchase those shares to boost EPS to meet the target. I don't know if that's true, but the market certainly reacted negatively to the earnings, and this fact might have contributed to the market's concern. Year-over-year, net cash (cash minus debt) increased by $768 million, but is still negative overall.

On the working capital side of things, the Flowie is an unimpressive 1.89. Seeking answers, I compared Pfizer's accounts receivable, inventory, and accounts payable -- as a percentage of sales -- to three of its competitors:

As a % Schering- Warner-
of Sales Pfizer Plough Merck Lambert
Accounts
Receivable 88.4% 49.6% 41.6% 58.9%
Inventory 43.4% 38.2% 33.0% 30.5%
Accounts
Payable 16.7% 42.5% 45.0% 60.8%

Check it out -- as a percentage of sales, Pfizer's accounts receivable and accounts payable are off the charts relative to its competitors. If that sentence reads like Greek to you, please take a momentary detour over to Rule Maker Step 7, where we explain the Flowie in simple language. And, as always, help is just a click away in the Rule Maker Beginners folder. According to the footnotes in the 10-Q, the high level of accounts receivables is due to the higher contractual payment terms of alliance revenue receivables, along with the aforementioned strong growth in alliance revenues. The only explanation given for the overly-low accounts payable is "the timing of payments." Okay, that helps. I put a call in to the company, but didn't receive an answer in time for publication. As soon as I find out anything, I'll post my findings to the Rule Maker Companies board.

In sum, Pfizer's first quarter was one of good direction, but there's still plenty of room for improvement on the balance sheet. On the Ranker, the company scores 42 points, which is six less than the last time we scored Pfizer using its fiscal 1998 results. Nothing to quake over, but improvement is definitely needed on the balance sheet going forward.

Looking ahead, Pfizer has promise galore. The company has been spending heavily on research and development (R&D) for years. During the first quarter, Pfizer's R&D spending was well-ahead of the competition, not only as a percentage of sales, but on an absolute basis, as well:

Q1 1999 R&D Spending ($ millions)
Pfizer $ 655
Merck 442
Schering-Plough 262
Warner-Lambert 234

The R&D pay-off is beginning to show. New medicines in the advanced stage of development create the potential for more than 20 products in Pfizer's drug portfolio by early in the next decade. Treatments for migraine headaches, irregular heart rhythm, schizophrenia, diabetes (inhalable insulin), and breast cancer are just a few of the projects in the works. In addition to these life-saving drugs, Pfizer is also working on life-enhancing drugs, called cosmeceuticals, that aim to improve skin pigmentation, skin wrinkling, and hair loss.

In conclusion, Pfizer's future looks bright as ever. Nevertheless, in the quarters ahead, we'll be watching the balance sheet closely looking for signs of improvement.

For more on Pfizer, I highly recommend Forbes' January Company of the Year article.

See ya on the boards,

Matt



To: Dan Spillane who wrote (7757)5/28/1999 2:00:00 PM
From: Anthony Wong  Respond to of 9523
 
EAS MEETING: Lipitor More Effective Than Zocor And Baycol For Lowering Cholesterol

ATHENS, GREECE - May 27, 1999 -- Building on
existing data, two new studies presented at the annual
congress of the European Atherosclerosis Society (EAS),
now provide further evidence of the superior
cholesterol-lowering efficacy of Parke-Davis' and
Pfizer's Lipitor(R) (atorvastatin calcium tablets).

In the first study known as Triple A (Australian
Atorvastatin Assessment), a significantly greater number
of patients reached total cholesterol goals on Lipitor than
patients taking Zocor(R) (simvastatin). In the second
study, Atorvastatin Versus Cerivastatin (Baycol[R]),
Lipitor demonstrated a greater cholesterol-lowering effect
than cerivastatin. This study completes the comparative
review of Lipitor versus all available statin therapies.

"Atorvastatin is the most efficacious of the HMG-CoA
reductase inhibitors at reducing low density lipoprotein
[LDL-C] cholesterol," said professor Phillip Barter,
department of medicine, University of Adelaide, South
Australia. "These studies provide further evidence of the
impressive cholesterol-altering effects of atorvastatin."

In the Atorvastatin Versus Cerivastatin study, atorvastatin
was found to be a more effective cholesterol-lowering
therapy at its starting dose of 10 mg/day than cerivastatin
at its maximum approved dose of 300 micrograms/day in
patients with high cholesterol. Cerivastatin is the latest
addition to the class of drugs known as statins.

Compared with the maximum approved dose of
cerivastatin, the 10 mg starting dose of atorvastatin
produced significantly greater reductions from baseline in
LDL-C (37.7 percent versus 30.2 percent), total
cholesterol (TC) (27.5 percent versus 22.2 percent) and
apolipoprotein B (Apo B) (28.6 percent versus 21.2
percent) and a significantly greater increase from baseline
in high density lipoprotein cholesterol (HDL-C) (6.8
percent versus 4.3 percent).

Both atorvastatin and cerivastatin were well tolerated with
safety profiles similar to other members of the statin class.

In the six-week, multicentre, open-label, parallel-arm
study, a total of 215 patients with high cholesterol were
randomised to receive either atorvastatin 10 mg once
daily or cerivastatin 300 micrograms once daily. Efficacy
was determined by measuring changes in lipid
parameters.

The Australian Atorvastatin Assessment (Triple A) study
supports the superiority of 10 mg of atorvastatin in
achieving TC targets compared with 10 mg of simvastatin
regardless of baseline cholesterol. Atorvastatin took
significantly more patients to TC target of less than 5.0
mmol/L than simvastatin at all points within the study
regardless of baseline cholesterol. After 24 weeks, 83.1
percent of atorvastatin treated patients reached target
versus 65.9 percent on simvastatin (plus or minus
cholestyramine).

"The Triple A results are exciting because they show that
the 10 mg starting dose of atorvastatin is an effective
treatment for primary care patients with varying levels of
baseline cholesterol," said Dr. Richard O'Brien,
department of medicine, Monash University, Victoria,
Australia.

The 24-week, open-label, randomised study enrolled
1,028 hypercholesterolaemic men and women aged 18 to
76. Designed to replicate the real world where these
patients are treated by general practitioners, the study
involved more than 240 general practice offices. Patients
with comparable baseline lipid levels were randomised to
either atorvastatin or simvastatin. An initial drug dose of
10 mg daily for each agent was doubled at six-week
intervals if the target TC level of less than 5.0 mmol/L
(190 mg/dL) had not been achieved. The maximum dose
of atorvastatin was 80 mg, while the maximum dose of
simvastatin was 40 mg supplemented if necessary with 4
g of cholestyramine. Once a patient achieved the target of
less than 5.0 mmol/L, the dose remained constant until the
end of the six months.

Atorvastatin is indicated as an adjunct to diet to reduce
elevated total-C, LDL-C, Apo B, and TG levels in
patients with primary hypercholesterolemia and mixed
dyslipidemia. The recommended starting dose of
atorvastatin is 10 mg once daily. The dosage range is 10
mg to 80 mg once daily. Atorvastatin is generally well
tolerated. Adverse reactions usually have been mild and
transient, with fewer than 2 percent of patients being
discontinued from clinical trials due to side effects related
to atorvastatin. This rate of discontinuation was
comparable to that of placebo. The most frequent
adverse effects of atorvastatin are constipation, flatulence,
dyspepsia and abdominal pain.

It is recommended that liver function tests be performed
prior to and at 12 weeks following both the initiation of
therapy and any elevation of dose, and periodically
thereafter. Myopathy should be considered in any patient
with diffuse myalgias, muscle tenderness or weakness
and/or marked elevation of creatine phosphokinase
(CPK).

pslgroup.com