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In the wake of several spectacular P-3 experimental drug failures, some investors (me, for example) have concluded there is little difference between rank gambling and investing in thinly-capitalized biotechnology companies with nothing but a good story and a literate PR department. Past and present FDA practice compels such entites to endure years of expensive P-1, P-2, and P-3 tests, all the while enabling them to dilute shareholder value with toxic convertibles, secondary issues, and magnanimous options for executives, board members, and their buddies. This thread is intended to help minimize by risk by limiting discussion to companies with promising compounds or medical devices that are on the very threshhold of FDA approval.
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