Discussion and file folder for RNAi stuff. I know of only one company that is a public, pure play, and will attach an unmanaged portfolio. That company is RNAI, the revamped RZYM. Another player is QGENF, but it is hardly pure. Private companies include suppliers Imgenex, Ambion, Novagen, and Dharmacon, as well as therapeutic competitor to RNAI, Anlynam.
Here are some important general articles relating to siRNA and delivery issues. All are free and full text!
RNA interference is mediated by 21- and 22-nucleotide RNAs
genesdev.org
Small Interfering RNAs: A Revolutionary Tool for the Analysis of Gene Function and Gene Therapy
molinterv.aspetjournals.org
RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells
pnas.org
Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells
genesdev.org
A DNA vector-based RNAi technology to suppress gene expression in mammalian cells
pnas.org
Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems
pnas.org
Retroviral delivery of small interfering RNA into primary cells
pnas.org
Links to company specific threads (pure plays only):
Sirna: Subject 10854
Alnylam (now publlic): Subject 54862 |
