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Biotech / Medical
RNAi
An SI Board Since May 2003
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Emcee:  tuck Type:  Unmoderated
Introduction Compact
Discussion and file folder for RNAi stuff. I know of only one company that is a public, pure play, and will attach an unmanaged portfolio. That company is RNAI, the revamped RZYM. Another player is QGENF, but it is hardly pure. Private companies include suppliers Imgenex, Ambion, Novagen, and Dharmacon, as well as therapeutic competitor to RNAI, Anlynam. 2010 Update: more public companies are around: a few are mentioned on SI but don't have threads: Silence Therapeutics (SLN.L), Tekmira (TKM.TO), RXi (RXII), Rosetta Genomics (ROSG) (more of a diagnostics play, I thought), Benitec (BLT.AX), & Targeted Genetics (TGEN). Some of the foreign companies have American listings on the pink sheets, but I doubt they trade much, so caveat emptor.

Here are some important general articles relating to siRNA and delivery issues. All are free and full text!

RNA interference is mediated by 21- and 22-nucleotide RNAs
genesdev.org

Small Interfering RNAs: A Revolutionary Tool for the Analysis of Gene Function and Gene Therapy
molinterv.aspetjournals.org

RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells
pnas.org

Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells
genesdev.org

A DNA vector-based RNAi technology to suppress gene expression in mammalian cells
pnas.org

Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems
pnas.org

Retroviral delivery of small interfering RNA into primary cells
pnas.org

Links to company specific threads (pure plays only):

Sirna: Subject 10854

Alnylam (now publlic): Subject 54862

Link to blog on RNAi therapeutics:

rnaitherapeutics.blogspot.com
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671One could argue that the lack of cardiac data in the label won't affect scrituck-8/10/2018
670Yup. MC is 10 billion (doom!), but look at the number and breadth of projects (scaram(o)uche-8/10/2018
669ALNY: The label is pretty restricted, and they'll only get a fraction of thetuck-8/10/2018
668Fifteen years...... the first FDA approval of a new class of drugs called smallscaram(o)uche-8/10/2018
667>> The field is attracting an incredible array of the very best. The best scaram(o)uche-9/20/2017
666[Short-interfering RNAs Induce Retinal Degeneration via TLR3 and IRF3] >>tuck-10/13/2011
665and now Rxi is spinning out their RNAi stuff...mopgcw-9/26/2011
664And Merck closes the former Sirna facility, apparently having given up on RNAi etuck-8/2/2011
663PFE pulls back from Quark program in DME: siliconinvestor.comDewDiligence_on_SI-3/21/2011
662Similar theme. NYT: <i>Drugmakers’ Fever for the Power of RNA Interferentom pope-2/8/2011
661<b>Drug giants turn their backs on RNA interference</b> nature.com idos-11/24/2010
660And now Roche drops RNAi programs in its restructuring: pipeline.corante.com Wtuck-11/18/2010
659NVS Ends RNAi Collaboration with ALNY: siliconinvestor.comDewDiligence_on_SI-9/23/2010
658Silence Therapeutics Adds New Patent to Industry Leading Structural ModificationA.J. Mullen-8/21/2010
657Silence Therapeutics Announces Issuance of New U.S. Patent Broadly Covering MethA.J. Mullen-6/14/2010
656<b>Silencing approach saves monkeys from Ebola: study</b> Maggie Foidos-5/28/2010
655Should have. All I can give you is an interview with with Merck's Alan Sachidos-4/30/2010
654There's a notable omission from that list: MRK! Shouldn't the Sirna dealDewDiligence_on_SI-4/30/2010
653<b>Key RNAi-Based Drugs in the Clinic</b> genomeweb.com April 29, idos14/30/2010
652Feuerstein has a brief listing of companies involved in RNAi. No discussion, justom pope-4/3/2010
651It is a long way to go yet. There are currently several means of delivery and moidos-3/31/2010
650Color from Lowe and commenters on Calando's targeted delivery. Manufacturintuck-3/29/2010
649Targeted delivery of siRNA into cancerous tissue: <b>Cancer genes silenceidos-3/25/2010
648UPDATE 1-Tekmira, Pfizer to collaborate on RNAi delivery system Thomson ReutersIan@SI-3/16/2010
647I just listened to a February presentation by the CEO of Silence Therapeutics, vA.J. Mullen-3/9/2010
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