Just to clear up any confusion, this thread is devoted to the technique of RNA interference and the companies that practice it or supply reagents for its practice. Note the small "i" in the subject title; it's not just about RNAI the stock.
Anyhow, here's the latest in product offerings from Sequitur, which seems to address some of concerns with siRNAs I've raised ion other posts here.
>>NATICK, Mass., May 27 /PRNewswire/ -- Sequitur, Inc. announced today the launch of its STEALTH(TM) RNAi program for therapeutic development and research applications (patents pending). RNAi, a form of double-stranded RNA that can inhibit gene expression in a sequence-specific manner, was co-invented by Sequitur's scientific advisor Prof. Craig Mello of the Howard Hughes Medical Institute at the University of Massachusetts Medical School. RNAi is widely used in drug discovery and development programs throughout the pharmaceutical industry to specifically inhibit the expression of disease- causing genes.
Sequitur's STEALTH RNAi technology is distinct from competing siRNA technology and offers several improvements over standard RNAi including:
-- Avoidance of cellular surveillance against RNAi (interferon/PKR
response)
-- Avoidance of blood and cellular defenses that ordinarily destroy RNAi
(nucleases)
-- Enhanced activity
Tod Woolf, Sequitur's CEO, noted, "We are excited to introduce our advanced STEALTH RNAi, a product that is the result of six years of RNA technology development at Sequitur. We are pleased to offer a product for research use and therapeutic development that addresses some of the major challenges for use of RNAi in animal models of human diseases."
Sequitur is a privately held corporation that offers collaborations to develop therapeutic RNAi compounds and collaborations to validate and discover drug targets. Sequitur also offers a line of products and services relating to gene expression and gene detection, including the RNA Catcher high throughput RNA isolation system. Sequitur's clients include Bristol-Myers Squibb, Procter and Gamble, Abbott Laboratories, Incyte, GlaxoSmithKline, Pfizer, Genentech, Roche, Schering-Plough, Wyeth and others.<<
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Cheers, Tuck |
