Collagen delivery of siRNAs. Interesting development. Any thoughts? TIA.
Looks like a bit of the hype deflated in Sirna's stock, but looks like it has reached a new trading range. Meanwhile ALNY has traded down almost 20%. Does anyone follow ALNY closely enough to have a view on whether this is a buying opportunity?
Cheers,
Thomas
cancerpage.com
Collagen Method Delivers siRNA To Prostate Cancer Bone Metastases
NEW YORK AUG 08, 2005 (Reuters Health) - Although gene silencing with small interfering RNAs (siRNAs) has shown potential as an anti-cancer approach, systemically delivered siRNAs have not yet been tested against bone-metastatic tumors. Now, in an animal study, researchers show that atelocollagen can be used to efficiently deliver siRNA to these tumors.
As reported in the August 8th early edition of the Proceedings of the National Academy of Sciences, Dr. Takahiro Ochiya, from the National Cancer Center Research Institute in Tokyo, and colleagues used siRNA complexed with atelocollagen to reduce expression of a luciferase gene in bone-metastatic prostate tumor cells in mice.
The findings indicate that the therapeutic compound reached the bone metastases 24 hours after injection and remained there, intact, for at least 3 days.
By coupling the atelocollagen with different siRNAs, the investigators were able to efficiently inhibit the growth of bone metastases. Moreover, this approach appeared to be reliable and safe with no effect on serum levels of interferon-gamma or interleukin-12.
"To our knowledge, our results present the first evidence that gene silencing by means of systemic delivery of siRNA/atelocollagen complexes may have therapeutic potential in the treatment of advanced prostate cancer with bone metastasis," the authors conclude.
SOURCE:
Proc Natl Acad Sci USA 2005. |
