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Biotech / Medical : Micromet Inc (MITI)
MITI 0.120+33.3%Dec 11 12:18 PM EST
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From: Arthur Radley12/7/2009 8:32:36 AM
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Micromet's Blinatumomab in patients with non-hodgkins lymphoma (MITI) 6.91 : Co announces the publication of a poster with new data from its ongoing phase 1 clinical trial of its product candidate blinatumomab in patients with non-Hodgkin's lymphoma. The new data presented at A.S.H. show that 100% of evaluable patients (12 of 12 patients) with relapsed/refractory N.H.L., who were treated with blinatumomab at a dose level of 60 microgram/squaremeter per day, had an objective partial or complete response after their first 4-8 weeks of treatment. The responses were measured based on Cheson/IWG criteria and were confirmed by independent review. One patient at the 60-microgram dose level was not evaluable because of an adverse event that resulted in the discontinuation of treatment after two days. The longest duration of a response without re-treatment is currently 20 months. The response in 6 of the 12 evaluable patients is ongoing. The 60-microgram dose level has been selected for further clinical studies in patients with B-cell lymphoma. At the 60-microgram dose level, the most common adverse events of any grade and irrespective of drug relationship were pyrexia (100%), lymphopenia (77%), leukopenia (69%), C-reactive protein increase (62%), and headache (69%) Most adverse events occurred early during treatment and improved or resolved during treatment. The most common grade 3 and 4 adverse event was lymphopenia (77%).
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