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Biotech / Medical : Elan Corporation, plc (ELN)

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To: D.Lu who wrote (10258)	3/26/2010 8:57:18 AM
From: IRWIN JAMES FRANKEL	4 Recommendations of 10345

Hi D Lu, I do not think it will be hard to enroll. My wife was a Copaxone failure. Ifn antibodies degrading the utility of the other class of drug is just a matter of time and the higher the dose the shorter the time to resistance. It will take a long time to run the trial and get meaningful results. I wrote the rest of this post for IH, hope is of interest: Switching study - Copaxone to Tysabri My wife (who has RRMS) was on Copaxone for many years and did fairly well on it - that is until she had two serious exacerbations within one year. Her doctor pronounced the situation a treatment failure and suggested she shift to Tysabri. She has now been on T for over 2 years without any apparent exacerbation. I told the story of her progress in a series of posts that can be accessed here: Message 25078797 (By moving to the prior posts you can read the account.) From my wife's experience and what I hear about others who have moved to T after being treatment failures, this "switching" study will support the case for moving to T when other treatments fail. Unfortunately, it will take years for meaningful data. ij

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