continued from:
Message 3216517
"Phentolamine, which has been shown to have the potencial to induce erection when injected intracavernosally, ..."
Please look at that:
REFERENCE 1. (cited by Asensio)
J Urol 1988 Dec;140(6):1415-1416
Erectile responses to intracavernous papaverine and
phentolamine: comparison of single and combined
delivery.
Stief CG, Wetterauer U
In a prospective study of 15 consecutive impotent patients we evaluated the erectile responses to intracavernous injections of standardized doses of papaverine and phentolamine alone and incombination. Of the 15 patients 13 achieved a full erection with the drug combination, whereas only 6 achieved a full erection with papaverine and 1 with phentolamine. Our results suggest an effective alternative to the use of papaverine alone, whose long-term sequelae have been shown to be deleterious.
REFERENCE 2
Br J Urol 1989 Jan;63(1):95-97
Effect of phentolamine on venous return in human
erection.
Wespes E, Rondeux C, Schulman CC
A group of 25 patients underwent Doppler penile blood examination and cavernometry before
and after 5 mg of phentolamine injected intracavernously. The organic or psychogenic nature of impotence was determined by psychological testing, the intracavernous injection of papaverine, hormonal evaluation, neurological examination, Doppler penile blood flow measurement and cavernometry for vascular investigations. The intracavernous injection of phentolamine had no effect on the venous return and it provoked penile arterial dilatation. The erectile angle, which was also measured, was less evident than after the injection of papaverine. The results confirmed the fact that an increase in arterial inflow alone is not sufficient to induce a rigid erection in man.
Correct phrase in the patemt should be:
"Phentolamine, which has been shown to have NO (or INSUFFICIENT) potencial to induce erection when injected intracavernosally, ..."
Q1. Do you think that 40 mg tablet may provide higher phentolamine concentration in specific area than 5 mg intracavernous injection?
Q2. Could someone question the integrity of authors based on this phrase only?
Q3. What kind of information patients really got before they signed? |
