Bernie, Thanks for the info. I realize this is older, but I don't remember seeing it here. squetch
Proceedings of the National Academy of Sciences
Volume 93, Number 13; Pages: 6610-6615
Medical Sciences
Gadolinium(III) texaphyrin: A tumor selective radiation sensitizer that is detectable by MRI
Stuart W. Young, Fan Qing, Anthony Harriman, Jonathan L. Sessler, William C. Dow, Tarak D. Mody, Gregory W. Hemmi,
Yunpeng Hao, Richard A. Miller
c 1996 by the National Academy of Sciences
ABSTRACT Gadolinium(III) texaphyrin (Gd-tex2+) is representative of a new class of radiation sensitizers detectable by magnetic resonance imaging (MRI). This porphyrin-like complex has a high electron affinity [E 12 (red.) ~ 0.08 V versus normal hydrogen electrode] and forms a long-lived pi-radical cation upon exposure to hydrated electrons, reducing ketyl radicals, or superoxide ions. Consistent with these chemical findings, Gd-tex2+ was found to be an efficient radiation sensitizer in studies carried out with HT29 cells in in vitro as well as in in vivo single and multifraction irradiation studies with a murine mammary carcinoma model. Selective localization of Gd-tex2+ in tumors was confirmed by MRI scanning.
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