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Please also see discussions about PCYC under QLT area. Pharmacyclics is a company with three products in clinical development and multiple compounds in preclinical development. Their products are: Gd-Tex (gadolinium texophyrin), a radiation sensitizer. This product is in Phase I trials, which are still open for enrollment. They are studying effects on brain metastases, as well as looking at MDT's (maximum tolerable dose). Lu-Tex (lutetium texaphyrin PCI-0123), a light activated drug being studied for treatment of various cutaneous tumors, including Kaposis Sarcoma, melanoma, breast CA, and others. It is in Phase I trials, the interim results of which looked very favorable for both efficacy and toxicity. In fact, it could be a very important compound when and if they demonstrate its efficacy in trials, because the drug has a fairly short half-life, which limits its toxicity. Gadolite oral suspension, an MRI contrast agent for the GI tract. This is in Phase III trials and a NDA has been filed. I believe they will compete in a difficult but very promising market. The real question will be what , if any, advantages will Lu-Tex have over products being studied by QLT and PDT. The CEO of PCYC is Rich Miller who founded IDEC pharmaceuticals and he is supposedly a very bright guy and whatever he touches seems to work (both scientifically and for the shareholders). I am not a stock promoter nor am I a principal of the company, but I have been watching PCYC for several months and just bought some shares due to the recent weakness in its stock price, and because of the potential for its products. I would love to keep and ongoing discussion about this company. Doug | ||||||||||||||
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