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Biotech / Medical : Biotech Derivatives

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To: sim1 who wrote (100)	4/23/1999 1:43:00 AM
From: Mike McFarland	of 555

Finally got around to reading the DDT '99 schedule...this one caught my eye, I'll cross post it over to the Ariad thread. Specificity and Generality in Chemical Genetic Research Stuart L. Schreiber, Ph.D., Co-Director, Harvard Institute of Chemistry & Cell Biology, Harvard University Transcription profiling using DNA chips allows the specificity of small molecules to be assessed in a semi-quantitative way for the first time. We have used this method to show that the specificity of a small molecule approaches that of a deletion mutant, where the gene encoding the small molecule receptor is inactivated. Chemical genetic studies aimed at exploring signal transduction, the role of chromatin in gene regulation and the role of PIK-related kinases in cell cycle checkpoints are underway. We have undertaken two approaches to generalize chemical genetics. One approach uses small molecule dimerizers, which allow for the study of function of proteins for which small molecule ligands are not known. The second approach uses our ability to emulate many aspects of genetic principles to discover small molecule ligands, which could lead to a small molecule partner for every gene product.

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