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Biotech / Medical : VD's Model Portfolio & Discussion Thread -- Ignore unavailable to you. Want to Upgrade?

To: scaram(o)uche who wrote (7281)	12/11/1999 2:22:00 PM
From: Pseudo Biologist	Read Replies (1) \| Respond to of 9719

That is.... bex plus less flu tox equals better, but C2B8 plus less flu tox might not be as good as bex plus less flu tox. OK, here is an updated version of berblady's rankings: (1) Toxicity from less to more: Rituxan < Bex ~ Zev, Rit + Flu3 ~ Bex + Flu3 (guess) < Rit + Flu6 ~ Rit + CHOP (another guess, Rit+Flu6 could be actually more toxic, but we do not have enough data). Not known but interesting to think about Zev+Flu3, Zev+CHOP, Bex+CHOP? (2) Efficacy from less to more: Ritux < Bex ~ Zev < Ritux + Flu3 (guess) < Ritux+CHOP ~ Bex+Flu3 and Rit+Flu6?? I'll leave the cost rankings to Peter -g- PB

To: scaram(o)uche who wrote (7281)	12/11/1999 10:56:00 PM
From: Vector1	Respond to of 9719

<<Is it likely that the characterisitics of a murine MAb, long considered as deficiencies, can be harnessed to provide superior therapy for given indications?>> An thus the importance of the hot v. cold data. There is no definitive answer why Bex is showing continued action 6 months after infusion. My dilligence has uncovered two reasons. Reason 1. It takes time especially for bulky tumors to no longer show up on a scan. As I understand it even if the tumors are destroyed at 3 months they may show up as scar tissue on a C scan and thus the partial response at 3 months. Reason 2. As described by Rick and PB, in laymans terms, Bex (and prob Rit) stimulate the immune system to create its own antibodies which clean up any remaining tumor cells. This is of course unproven but quite exciting for long term patient outcomes. V1