Silicon Investor (SI) -- The First Internet Community

STOCKTALK

We've detected that you're using an ad content blocking browser plug-in or feature. Ads provide a critical source of revenue to the continued operation of Silicon Investor. We ask that you disable ad blocking while on Silicon Investor in the best interests of our community. If you are not using an ad blocker but are still receiving this message, make sure your browser's tracking protection is set to the 'standard' level.

Biotech / Medical : VD's Model Portfolio & Discussion Thread -- Ignore unavailable to you. Want to Upgrade?

To: Cytokine1 who wrote (7462)	1/13/2000 12:39:00 AM
From: Vector1	Read Replies (1) \| Respond to of 9719

Report from CLTR presentation at HQ. I thought CLTR make a very impressive presentation at HQ today and during the breakout the company elaborated on the much discussed delayed BLA filing. The primary reason for the BLA delay are difficulties in formatting the data in a manner that lends itself to an electronic filing and gives the FDA biologics division which has limited statistical resources the ability to extract the data they need. The company realized after meeting with the FDA that the process would be interactive and the the company would have to in effect act as staff statistician for the FDA and prepare analysis for them. Realizing that this would take a long time the company decided to update the data from the trials which make up the submission. The company did this to try and enhance thier label since the data is positive given that one of the main advantages of Bex is the length of the remissions it induces. The company was careful to say that they could not give an exact date on the filing but noted that significant progress has been made recently and expected to give the street guidance in about two weeks. I view this as good news and expect the filing to occur sometime in April. That is my view the company did not say that. While I can be fairly cynical (not as bad as Biowa) and I have been quite critical of CLTR for not being more interactive with the FDA from the beginning, I must say that I found Bingham to be sincere and highly credible. I think for better or worse the company has been caught in a situation where the Biologics division at the FDA has precious little time to review a very complicated filing and at the same time is trying to convert to the digital world. CLTR is the guinea pig. No time to whine about it they just need to deal with it and I think they are. The big positive of this story is the efficacy of Bex which is being proven over and over again. The company confirmed that in the Bex stand alone trial that had in the mid 60s complete response rate, over 2/3s of the CRs were at the molecular level. In my view this is quite impressive. The company repeated the ASH data on the Fludarabine trial. Indeed the company reported that to date only 3 patients from that trial (out of 30) have relapsed. IMO Fludarabine plus Bex will become the gold standard in NHL. In addition the company reported that the have completed enrollment of the trial on patients that have failed Rit. This is exactly the same trial that IDEC reported on at ASH for Zev with IMO mediocre results. NO COMPLETE REMISSIONS. The Bex data on patients who have failed RIt will be reported at next December's ASH. The timing is not coincidently around the time Bex will likely get approval from the FDA. The company said that the next ASH could not come soon enough and I can understand why. If the data on Rit refactory patients is good you can sign the death warrant for Zev. I remain extremely bullish on this stock. V1

To: Cytokine1 who wrote (7462)	1/13/2000 8:28:00 PM
From: Cytokine1	Read Replies (1) \| Respond to of 9719

VD's MODEL PORTFOLIO 1/13/00 Change $15906 UP 1.78% Started 4/9/97, $100K . INDEX ^IXB UP 4.77% YTD EQUITY CHANGE 21.5% # CURRENT DAILY CURRENT COST TOTAL %GAIN/ % OF SYMBOL SHRS PRICE CHANGE %CHG VALUE SHR COST LOSS TOTAL ======= ======= ======= ======= ======= ======= ======= ======= ======= ======= BTRN 3000 7.94 0.00 0.00% 23813 2.25 6750 252.8% 2.6% CGPI 2000 22.25 -0.38 -1.66% 44500 9.00 18000 147.2% 4.9% ABSC 1500 33.25 -4.50 -11.92% 49875 8.761 13141 279.5% 5.5% CELG 2000 59.63 2.88 5.07% 119250 27.10 54200 120.0% 13.1% MOGN 1500 16.19 0.31 1.97% 24281 8.667 13000 86.8% 2.7% CLTR 5500 25.63 -2.88 -10.09% 140938 16.76 92156 52.9% 15.5% SEPR 1000 119.88 3.03 2.59% 119875 84.71 84713 41.5% 13.2% NBIX 1000 27.88 -0.75 -2.62% 27875 6.00 6000 364.6% 3.1% TRMS 3000 33.13 0.75 2.32% 99375 21.77 65313 52.2% 10.9% GZTC 2000 14.88 -0.63 -4.03% 29750 7.737 15475 92.2% 3.3% INCY 1000 137.25 34.25 33.25% 137250 28.95 28954 374.0% 15.1% NPSP 2000 12.19 -1.06 -8.02% 24375 5.50 11000 121.6% 2.7% EPPH.OB 3000 5.88 0.00 0.00% 17625 6.25 18750 -6.0% 1.9% GLIA 3500 14.31 -0.69 -4.58% 50094 17.5625 61469 -18.5% 5.5% STOCK ______ ______ ______ ______ 908875 488920 85.9% 100.0% SHORT SALE CREDIT ______ ______ 0 MARGIN MTCE. EQUITY 83.8% MIN 30% (147219) BUYING POWER $ ______ 614437 EQUITY (NAV) ______ ______ ______ 761656 100000 661.7% ^IXB INDEX 975.19 44.41 4.77% 302.42 222.5% NOTES: OPEN orders subject to available buying power--- BUY 500 NBIX @ $20 . BUY 500 SEPR @ $90 . BUY 500 SEPR @ $95 . . . 01/11/1999 -16000 BUY 1000 GLIA @ $16.00 01/11/2000 -18750 BUY 3000 EPPH.OB @ $6.25 01/07/2000 -30000 BUY 500 CELG @ $60.00 01/04/2000 -20712.5 BUY 200 SEPR @ $103.5625